ArticleAmerican journal of physiology. Renal physiology2016
Neuroanatomic and behavioral correlates of urinary dysfunction induced by vaginal distension in rats.
Article in American journal of physiology. Renal physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Variations in bladder pain syndrome/interstitial cystitis (IC) definitions, pathogenesis, diagnostics and treatment: a systematic review and evaluation of national and international guidelines.International urogynecology journal · 2019Pooled it
- Ciliary neurotrophic factor (CNTF) contributes to pelvic organ prolapse by modulating collagen expression via the JAK2-STAT3 pathway.Journal of molecular histology · 2025Article
- Morphological examination of pelvic floor muscles in a rat model of vaginal delivery.BMC pregnancy and childbirth · 2024Article
- Efficacy and sex-specific outcomes after six episodes of percutaneous tibial nerve stimulation treatment on overactive bladder syndrome symptoms.Frontiers in urology · 2024Article
- The effects of progesterone on the healing of obstetric anal sphincter damage in female rats.Open medicine (Warsaw, Poland) · 2023Article
- Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats.Scientific reports · 2021Article
- Use of balloon tamponade in management of vaginal laceration and its possible complication of urinary stress incontinence: a case report.BMC pregnancy and childbirth · 2020Article
- Stromal derived factor-1 plasmid as a novel injection for treatment of stress urinary incontinence in a rat model.International urogynecology journal · 2020Article
- Electrical stimulation of the pudendal nerve promotes neuroregeneration and functional recovery from stress urinary incontinence in a rat model.American journal of physiology. Renal physiology · 2018Article
- Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits.International neurourology journal · 2018Article
- Effects of multiple simulated birth traumas on urethral continence function in rats.American journal of physiology. Renal physiology · 2017Article
- Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits.BioMed research international · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The aim of the present study was to use a model of simulated human childbirth in rats to determine the damage to genitourinary structures and behavioral signs of urinary dysfunction induced by vaginal distension (VD) in female rats. In experiment 1, the length of the genitourinary tract and the nerves associated with it were measured immediately after simulated human delivery induced by VD or sham (SH) procedures. Electroneurograms of the dorsal nerve of the clitoris (DNC) were also recorded. In experiment 2, histological characteristics of the bladder and major pelvic ganglion of VD and SH rats were evaluated. In experiment 3, urinary parameters were determined in conscious animals during 6 h of dark and 6 h of light before and 3 days after VD or SH procedures. VD significantly increased distal vagina width (P < 0.001) and the length of the motor branch of the sacral plexus (P < 0.05), DNC (P < 0.05), and vesical nerves (P < 0.01) and decreased DNC frequency and amplitude of firing. VD occluded the pelvic urethra, inducing urinary retention, hematomas in the bladder, and thinness of the epithelial (P < 0.05) and detrusor (P < 0.01) layers of the bladder. Major pelvic ganglion parameters were not modified after VD. Rats dripped urine in unusual places to void, without the stereotyped behavior of micturition after VD. The neuroanatomic injuries after VD occur alongside behavioral signs of urinary incontinence as determined by a new behavioral tool for assessing micturition in conscious animals.
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