Evidence map›Paper›PMID 26936850›Full record

ArticleJIMD reports2016

Chronic Oral L-Carnitine Supplementation Drives Marked Plasma TMAO Elevations in Patients with Organic Acidemias Despite Dietary Meat Restrictions.

Marcus J Miller, Bret L Bostwick, Adam D Kennedy, Taraka R Donti, Qin Sun, V Reid Sutton, Sarah H Elsea

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JIMD reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marcus J MillerDepartment of Molecular and Human Genetics, Medical Genetics Laboratory, Baylor College of Medicine, Houston, TX, 77030, USA.
Bret L BostwickDepartment of Molecular and Human Genetics, Medical Genetics Laboratory, Baylor College of Medicine, Houston, TX, 77030, USA.
Adam D KennedyMetabolon Inc., Durham, NC, 27713, USA.
Taraka R DontiDepartment of Molecular and Human Genetics, Medical Genetics Laboratory, Baylor College of Medicine, Houston, TX, 77030, USA.
Qin SunDepartment of Molecular and Human Genetics, Medical Genetics Laboratory, Baylor College of Medicine, Houston, TX, 77030, USA.
V Reid SuttonDepartment of Molecular and Human Genetics, Medical Genetics Laboratory, Baylor College of Medicine, Houston, TX, 77030, USA.
Sarah H ElseaDepartment of Molecular and Human Genetics, Medical Genetics Laboratory, Baylor College of Medicine, Houston, TX, 77030, USA. elsea@bcm.edu.
Baylor College of Medicine · USBaylor Genetics · USMetabolon (United States) · US

Funding

MEDICAL GENETICS RESEARCH FELLOWSHIP PROGRAMT32GM007526 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee · 1985 to 2026
$11.4M
NIGMS NIH HHS T32 GM007526
6 · The paper itself

Abstract

Recent studies have implicated trimethylamine N-oxide (TMAO) in atherosclerosis, raising concern about L-carnitine, a common supplement for patients with inborn errors of metabolism (IEMs) and a TMAO precursor metabolized, in part, by intestinal microbes. Dietary meat restriction attenuates carnitine-to-TMAO conversion, suggesting that TMAO production may not occur in meat-restricted individuals taking supplemental L-carnitine, but this has not been tested. Here, we mine a metabolomic dataset to assess TMAO levels in patients with diverse IEMs, including organic acidemias. These data were correlated with clinical information and confirmed using a quantitative TMAO assay. Marked plasma TMAO elevations were detected in patients treated with supplemental L-carnitine, including those on a meat-free diet. On average, patients with an organic acidemia had ~45-fold elevated [TMAO], as compared to the reference population. This effect was mitigated by metronidazole therapy lasting 7 days each month. Collectively, our data show that TMAO production occurs at high levels in patients with IEMs receiving oral L-carnitine. Further studies are needed to determine the long-term safety and efficacy of chronic oral L-carnitine supplementation and whether suppression or circumvention of intestinal bacteria may improve L-carnitine therapy.

Identifiers

PMID26936850
PMCPMC5110437
OpenAlexW2289014200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.