ArticleJournal of experimental botany2016
Pepper CabZIP63 acts as a positive regulator during Ralstonia solanacearum or high temperature-high humidity challenge in a positive feedback loop with CaWRKY40.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 100 citations in OpenAlex.
- Molecular mechanisms and agronomic strategies for thermotolerance in chili pepper (Capsicum annuum L.).Plant cell reports · 2026Review
- bZIP Transcription Factor PobZIP8 Positively Mediates Heat Stress Tolerance and Negatively Regulates the Growth and Development of Pleurotus ostreatus.Microbial biotechnology · 2026Article
- Scientific trends and discoveries on heat tolerance in pepper plants (Capsicum spp.): a bibliometric analysis.Biologia futura · 2026Review
- Chemical Priming by Neonicotinoids Unveils CaNEN4 as a Susceptibility Gene Against Phytophthora capsici in Pepper.Molecular plant pathology · 2026Article
- Molecular mechanisms and breeding strategies for heat tolerance in vegetable crops under global warming.Horticulture research · 2026Article
- Article
- Molecular evolution of the bZIP family in allotetraploid Gossypium and GhbZIP017 function under drought stress.Plant cell reports · 2025Article
- Unveiling the evolution of VIP1 subgroup bZIP transcription factors in plants and the positive effects of BdiVIP1A on heat stress response in Brachypodium distachyon.Plant cell reports · 2025Article
- A linker histone acts as a transcription factor to orchestrate malic acid accumulation in apple in response to sorbitol.The Plant cell · 2024Article
- Article
- CaIAA2-CaARF9 module mediates the trade-off between pepper growth and immunity.Plant biotechnology journal · 2024Article
- Pepper immunity against Ralstonia solanacearum is positively regulated by CaWRKY3 through modulation of different WRKY transcription factors.BMC plant biology · 2024Article
- A 14-3-3 Protein Ca16R Acts Positively in Pepper Immunity againstPlants (Basel, Switzerland) · 2024Article
- CaSTH2 disables CaWRKY40 from activating pepper thermotolerance and immunity againstHorticulture research · 2024Article
- Genome-wide analysis of bZIP gene family members in Pleurotus ostreatus, and potential roles of PobZIP3 in development and the heat stress response.Microbial biotechnology · 2024Article
- Differential CaKAN3-CaHSF8 associations underlie distinct immune and heat responses under high temperature and high humidity conditions.Nature communications · 2023Article
- PMT6 Is Required for SWC4 in Positively Modulating Pepper Thermotolerance.International journal of molecular sciences · 2023Article
- Divergence of functions and expression patterns of soybean bZIP transcription factors.Frontiers in plant science · 2023Review
- Putative Transcription Factor Genes Associated with Regulation of Carotenoid Biosynthesis in Chili Pepper Fruits Revealed by RNA-Seq Coexpression Analysis.International journal of molecular sciences · 2022Article
- Viromes of 15 Pepper (International journal of molecular sciences · 2022Review
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Authors and funding
25 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CaWRKY40 is known to act as a positive regulator in the response of pepper (Capsicum annuum) to Ralstonia solanacearum inoculation (RSI) or high temperature-high humidity (HTHH), but the underlying mechanism remains elusive. Herein, we report that CabZIP63, a pepper bZIP family member, participates in this process by regulating the expression of CaWRKY40. CabZIP63 was found to localize in the nuclei, be up-regulated by RSI or HTHH, bind to promoters of both CabZIP63(pCabZIP63) and CaWRKY40(pCaWRKY40), and activate pCabZIP63- and pCaWRKY40-driven β-glucuronidase expression in a C- or G-box-dependent manner. Silencing of CabZIP63 by virus-induced gene silencing (VIGS) in pepper plants significantly attenuated their resistance to RSI and tolerance to HTHH, accompanied by down-regulation of immunity- or thermotolerance-associated CaPR1, CaNPR1, CaDEF1, and CaHSP24. Hypersensitive response-mediated cell death and expression of the tested immunity- and thermotolerance-associated marker genes were induced by transient overexpression (TOE) of CabZIP63, but decreased by that of CabZIP63-SRDX. Additionally, binding of CabZIP63 to pCaWRKY40 was up-regulated by RSI or HTHH, and the transcript level of CaWRKY40 and binding of CaWRKY40 to the promoters of CaPR1, CaNPR1, CaDEF1 and CaHSP24 were up-regulated by TOE of CabZIP63. On the other hand, CabZIP63 was also up-regulated transcriptionally by TOE of CaWRKY40. The data suggest collectively that CabZIP63 directly or indirectly regulates the expression of CaWRKY40 at both the transcriptional and post-transcriptional level, forming a positive feedback loop with CaWRKY40 during pepper's response to RSI or HTHH. Altogether, our data will help to elucidate the underlying mechanism of crosstalk between pepper's response to RSI and HTHH.
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