Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of Ischemic Preconditioning on Endurance Running Performance in the Heat.Journal of sports science & medicine · 2024Trial
- Ischemic preconditioning has no effect on maximal arm cycling exercise in women.European journal of applied physiology · 2020Trial
- Ischemic preconditioning does not alter muscle sympathetic responses to static handgrip and metaboreflex activation in young healthy men.Physiological reports · 2017Trial
- No influence of ischemic preconditioning on running economy.European journal of applied physiology · 2017Trial
- Effects of Remote Ischemic Conditioning on Cardiovascular Responsiveness in Healthy Individuals.Life (Basel, Switzerland) · 2025Article
- Ischemic preconditioning and exercise performance: are the psychophysiological responses underestimated?European journal of applied physiology · 2023Review
- Remote ischaemic preconditioning - translating cardiovascular benefits to humans.The Journal of physiology · 2022Review
- Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors.European journal of applied physiology · 2022Article
- Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: A narrative review.Frontiers in physiology · 2022Review
- Sex differences in fatigability after ischemic preconditioning of non-exercising limbs.Biology of sex differences · 2020Article
- A brief bout of exercise in hypoxia reduces ventricular filling rate and stroke volume response during muscle metaboreflex activation.European journal of applied physiology · 2020Article
- Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia.European journal of applied physiology · 2019Article
- Ischemic Preconditioning and Exercise Performance: An Ergogenic Aid for Whom?Frontiers in physiology · 2018Article
- Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise.Frontiers in physiology · 2018Article
- Combining remote ischemic preconditioning and aerobic exercise: a novel adaptation of blood flow restriction exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Central vs. peripheral determinants of sympathetic neural recruitment: insights from static handgrip exercise and postexercise circulatory occlusion.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Effects of Six Months Training on Physical Capacity and Metaboreflex Activity in Patients with Multiple Sclerosis.Frontiers in physiology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic preconditioning (IP) has been shown to improve exercise performance and to delay fatigue. However, the precise mechanisms through which IP operates remain elusive. It has been hypothesized that IP lowers the sensation of fatigue by reducing the discharge of group III and IV nerve endings, which also regulate hemodynamics during the metaboreflex. We hypothesized that IP reduces the blood pressure response during the metaboreflex. Fourteen healthy males (age between 25 and 48 yr) participated in this study. They underwent the following randomly assigned protocol: postexercise muscle ischemia (PEMI) test, during which the metaboreflex was elicited after dynamic handgrip; control exercise recovery session (CER) test; and PEMI after IP (IP-PEMI) test. IP was obtained by occluding forearm circulation for three cycles of 5 min spaced by 5 min of reperfusion. Hemodynamics were evaluated by echocardiography and impedance cardiography. The main results were that after IP the mean arterial pressure response was reduced compared with the PEMI test (means ± SD +3.37 ± 6.41 vs. +9.16 ± 7.09 mmHg, respectively). This was the consequence of an impaired venous return that impaired the stroke volume during the IP-PEMI more than during the PEMI test (-1.43 ± 15.35 vs. +10.28 ± 10.479 ml, respectively). It was concluded that during the metaboreflex, IP affects hemodynamics mainly because it impairs the capacity to augment venous return and to recruit the cardiac preload reserve. It was hypothesized that this is the consequence of an increased nitric oxide production, which reduces the possibility to constrict venous capacity vessels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.