Evidence map›Paper›PMID 26936751›Full record

ReviewVeterinary pathology2016

Endocrinopathy and Aging in Ferrets.

V Bakthavatchalu, S Muthupalani, R P Marini, J G Fox

Open access · bronzeAbstract readReview
In one paragraph

Review in Veterinary pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Gastric neuroendocrine carcinoma (carcinoid) in a ferretThe Canadian veterinary journal = La revue veterinaire canadienne · 2022
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. A histopathological study on adrenal cysts in ferrets.Journal of toxicologic pathology · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. One What? Why GI Researchers Should Know and Care About the One Health Initiative.Cellular and molecular gastroenterology and hepatology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

V BakthavatchaluDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
S MuthupalaniDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
R P MariniDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
J G FoxDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA jgfox@mit.edu.
Massachusetts Institute of Technology · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Biomedical Research Training for Veterinary ScientistsT32OD010978 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FOX, JAMES G · 2012 to 2017
$2.2M
NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P30-ES002109NIH HHS T32 OD010978NIH HHS T32-OD010978-26
6 · The paper itself

Abstract

Ferrets have become more popular as household pets and as animal models in biomedical research in the past 2 decades. The average life span of ferrets is about 5-11 years with onset of geriatric diseases between 3-4 years including endocrinopathies, neoplasia, gastrointestinal diseases, cardiomyopathy, splenomegaly, renal diseases, dental diseases, and cataract. Endocrinopathies are the most common noninfectious disease affecting middle-aged and older ferrets. Spontaneous neoplasms affecting the endocrine system of ferrets appear to be increasing in prevalence with a preponderance toward proliferative lesions in the adrenal cortex and pancreatic islet cells. Diet, gonadectomy, and genetics may predispose ferrets to an increased incidence of these endocrinopathies. These functional proliferative lesions cause hypersecretion of hormones that alter the physiology and metabolism of the affected ferrets resulting in a wide range of clinical manifestations. However, there is an apparent dearth of information available in the literature about the causal relationship between aging and neoplasia in ferrets. This review provides a comprehensive overview of the anatomy and physiology of endocrine organs, disease incidence, age at diagnosis, clinical signs, pathology, and molecular markers available for diagnosis of various endocrine disorders in ferrets.

Indexed as

FerretsAge of OnsetAgingAnimalsEndocrine SystemEndocrine System DiseasesModels, AnimalPetsadrenal-associated endocrinopathyadrenocortical neoplasmagingand thyroidcystsdiabetes mellitusendocrine tumorsendocrinopathiesestrogen-induced anemiaferretgonadectomyinsulinomaislet cell tumormultiple endocrine neoplasianeuroblastomaovarypancreatic polypeptidomaparathyroidpheochromocytomapituitaryreviewteratomatestis

Identifiers

PMID26936751
PMCPMC5397995
OpenAlexW2289622627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.