ArticleMolecular medicine reports2016
Scutellaria baicalensis Georgi extract protects against alcohol‑induced acute liver injury in mice and affects the mechanism of ER stress.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
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- Identification of the Anti-ischemia-reperfusion Injury Effect of Baicalein fromCurrent medicinal chemistry · 2025Article
- Green Radish Polysaccharide Prevents Alcoholic Liver Injury by Interfering with Intestinal Bacteria and Short-Chain Fatty Acids in Mice.Foods (Basel, Switzerland) · 2024Article
- Phylogenomics analysis of Scutellaria (Lamiaceae) of the world.BMC biology · 2024Article
- Recent advances inHeliyon · 2024Review
- Effects of Scallop Mantle Toxin on Intestinal Microflora and Intestinal Barrier Function in Mice.Toxins · 2024Article
- Agarwood extract mitigates alcoholic fatty liver in C57 mice via anti‑oxidation and anti‑inflammation.Molecular medicine reports · 2023Article
- The Pharmacological Efficacy of Baicalin in Inflammatory Diseases.International journal of molecular sciences · 2023Review
- Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- Combined Effects of Methyldopa and Baicalein orPharmaceuticals (Basel, Switzerland) · 2022Article
- Challenges in Medicinal and Aromatic Plants DNA Barcoding-Lessons from the Lamiaceae.Plants (Basel, Switzerland) · 2022Review
- The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity.Frontiers in pharmacology · 2021Review
- Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response.Journal of natural medicines · 2020Article
- Characterization of Anti-Inflammatory and Antioxidant Constituents fromMolecules (Basel, Switzerland) · 2020Article
- Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice.Gastroenterology research and practice · 2020Article
- Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity ofChinese medicine · 2020Review
- Hepatoprotective Effects ofOxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of the present study were to examine the hepatoprotective effect of Scutellaria baicalensis Georgi extract (Scutellariae Radix extract; SRE) against acute alcohol‑induced liver injury in mice, and investigate the mechanism of endoplasmic reticulum (ER) stress. High performance liquid chromatography was used for the phytochemical analysis of SRE. Animals were administered orally with 50% alcohol (12 ml/kg) 4 h following administration of doses of SRE every day for 14 days, with the exception of normal control group. The protective effect was investigated by measuring the levels of aspartate transaminase (AST), alanine transferase (ALT) and triglyceride (TG) in the serum, and the levels of glutathione (GSH) and malondialdehyde (MDA) in liver tissues. The levels of glucose‑related protein 78 (GRP78) were detected using immunohistochemical localization and an enzyme‑linked immunosorbent assay. Hepatocyte apoptosis was assessed using terminal‑deoxynucleoitidyl transferase mediated nick end labeling. The SRE contained 31.2% baicalin. Pretreatment with SRE had a marked protective effect by reversing the levels of biochemical markers and levels of GRP78 in a dose‑dependent manner. The results of the present study demonstrated that pretreatment with SRE exerted a marked hepatoprotective effect by downregulating the expression of GRP78, which is a marker of ER stress.
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