ArticleScientific reports2016
Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A Microfabricated Branch Selection Platform for Quantitative Measurement of Leader-Follower Interaction Strength and Interaction Range in Collective Cell Migration.Micromachines · 2026Article
- Detecting existence of a hidden mediator between a pair of individual time series.Scientific reports · 2025Article
- Geometrical constraint change determines organized collective migration of follower cells.Scientific reports · 2025Article
- Long noncoding RNA MALAT1 is dynamically regulated in leader cells during collective cancer invasion.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling.BMC neuroscience · 2022Article
- Topography-induced large-scale antiparallel collective migration in vascular endothelium.Nature communications · 2022Article
- Chemoresistance is mediated by ovarian cancer leader cells in vitro.Journal of experimental & clinical cancer research : CR · 2021Article
- The effects of coating culture dishes with collagen on fibroblast cell shape and swirling pattern formation.Journal of biological physics · 2020Article
- The role of single cell mechanical behavior and polarity in driving collective cell migration.Nature physics · 2020Article
- Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models.Frontiers in physiology · 2020Review
- Consensus guidelines for the use and interpretation of angiogenesis assays.Angiogenesis · 2018Review
- TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics.Scientific reports · 2018Article
- Making Heads or Tails of It: Cell-Cell Adhesion in Cellular and Supracellular Polarity in Collective Migration.Cold Spring Harbor perspectives in biology · 2017Review
- Leaders in collective migration: are front cells really endowed with a particular set of skills?F1000Research · 2017Review
- Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
When blood vessels are injured, leader cells emerge in the endothelium to heal the wound and restore the vasculature integrity. The characteristics of leader cells during endothelial collective migration under diverse physiological conditions, however, are poorly understood. Here we investigate the regulation and function of endothelial leader cells by plasma lithography geometric confinement generated. Endothelial leader cells display an aggressive phenotype, connect to follower cells via peripheral actin cables and discontinuous adherens junctions, and lead migrating clusters near the leading edge. Time-lapse microscopy, immunostaining, and particle image velocimetry reveal that the density of leader cells and the speed of migrating clusters are tightly regulated in a wide range of geometric patterns. By challenging the cells with converging, diverging and competing patterns, we show that the density of leader cells correlates with the size and coherence of the migrating clusters. Collectively, our data provide evidence that leader cells control endothelial collective migration by regualting the migrating clusters.
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