ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016
Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 97 citations in OpenAlex.
- Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults.European journal of applied physiology · 2024Trial
- A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.JCI insight · 2022Trial
- Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways.American journal of physiology. Endocrinology and metabolism · 2021Trial
- Neuromuscular electrical stimulation and protein during bed rest increases CD11bApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2020Trial
- Trial
- Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- A semi-automated pipeline for quantitation of Pax7+, myonuclei, and cross-sectional area by fiber type.Physiological reports · 2026Article
- A semi-automated pipeline for morphological analysis of myonuclei along single muscle fibers.iScience · 2026Article
- The effect of nimesulide on skeletal muscle hypertrophy and load progression after 8 weeks of resistance training in wistar rats.Journal of muscle research and cell motility · 2026Article
- Specific collagen peptides supplementation increases collagen type I content in skeletal muscle after 12 weeks of high-load resistance training: a randomized controlled trial.Frontiers in physiology · 2026Article
- The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings.The Journal of physiology · 2025Review
- Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans.The Journal of physiology · 2025Article
- Nicotinamide and Pyridoxine in Muscle Aging: Nutritional Regulation of Redox, Inflammation, and Regeneration.Antioxidants (Basel, Switzerland) · 2025Review
- Complementing muscle regeneration-fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle.Nature communications · 2025Article
- Unraveling the bidirectional relationship between muscle inflammation and satellite cells activity: influencing factors and insights.Journal of muscle research and cell motility · 2025Review
- The dose-response effects of flurbiprofen, indomethacin, ibuprofen, and naproxen on primary skeletal muscle cells.Journal of the International Society of Sports Nutrition · 2024Article
- Time-of-day effects on ex vivo muscle contractility following short-term satellite cell ablation.American journal of physiology. Cell physiology · 2024Article
- Traumatic muscle injury.Nature reviews. Disease primers · 2023Review
- Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration.Skeletal muscle · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With this study we investigated the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in human skeletal muscle regeneration. Young men ingested NSAID [1200 mg/d ibuprofen (IBU)] or placebo (PLA) daily for 2 wk before and 4 wk after an electrical stimulation-induced injury to the leg extensor muscles of one leg. Muscle biopsies were collected from the vastus lateralis muscles before and after stimulation (2.5 h and 2, 7, and 30 d) and were assessed for satellite cells and regeneration by immunohistochemistry and real-time RT-PCR, and we also measured telomere length. After injury, and compared with PLA, IBU was found to augment the proportion of ActiveNotch1(+) satellite cells at 2 d [IBU, 29 ± 3% vs. PLA, 19 ± 2% (means ± sem)], satellite cell content at 7 d [IBU, 0.16 ± 0.01 vs. PLA, 0.12 ± 0.01 (Pax7(+) cells/fiber)], and to expedite muscle repair at 30 d. The PLA group displayed a greater proportion of embryonic myosin(+) fibers and a residual ∼2-fold increase in mRNA levels of matrix proteins (all P < 0.05). Endomysial collagen was also elevated with PLA at 30 d. Minimum telomere length shortening was not observed. In conclusion, ingestion of NSAID has a potentiating effect on Notch activation of satellite cells and muscle remodeling during large-scale regeneration of injured human skeletal muscle.-Mackey, A. L., Rasmussen, L. K., Kadi, F., Schjerling, P., Helmark, I. C., Ponsot, E., Aagaard, P., Durigan, J. L. Q., Kjaer, M. Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication.
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Registered trials
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