ArticleMolecular medicine reports2016
Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Chinese Herbal Medicine for Wilson's Disease: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2019Pooled it
- Synergistic effects of tanshinone IIA and mesenchymal stem cells on neuroprotection, cardiovascular repair, tissue regeneration, muscle protein synthesis, and gut microbiota modulation across neurodegenerative, cardiovascular, and regenerative disease models.Frontiers in cell and developmental biology · 2026Review
- Shufeiya Recipe Improves Monocrotaline-Induced Pulmonary Hypertension in Rats by Regulating SIRT3/FOXO3a and Its Downstream Signaling Pathways.Disease markers · 2022Article
- Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.Pharmaceutical biology · 2021Article
- Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages.Acta pharmacologica Sinica · 2021Article
- Protective Effects of Shenfuyixin Granule on HEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Recent Research Progress (2015-2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA.Frontiers in pharmacology · 2021Review
- Modified Lipid Nanocapsules for Targeted Tanshinone IIA Delivery in Liver Fibrosis.International journal of nanomedicine · 2021Article
- Neuroprotective Effect of CatalpolFrontiers in pharmacology · 2020Article
- Tanshinone IIA Promotes M2 Microglia by ERβ/IL-10 Pathway and Attenuates Neuronal Loss in Mouse TBI Model.Neuropsychiatric disease and treatment · 2020Article
- Therapeutic Effect of Tanshinone IIA on Liver Fibrosis and the Possible Mechanism: A Preclinical Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Tanshinone IIA improves diabetes mellitus via the NF-κB-induced AMPK signal pathway.Experimental and therapeutic medicine · 2018Article
- Heterophyllin B Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages by Suppressing the PI3K/Akt Pathways.Molecules (Basel, Switzerland) · 2018Article
- Tanshinone IIA Protects Endothelial Cells from H₂O₂-Induced Injuries via PXR Activation.Biomolecules & therapeutics · 2017Article
- Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos.Molecules (Basel, Switzerland) · 2017Article
- Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation.World journal of gastroenterology · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tanshinone IIA is extracted from the root of Salvia miltiorrhiza and used in traditional Chinese medicine for its anti-inflammatory activity and antioxidant effects. The aim of the present study was to investigate the potential protective effects of tanshinone IIA against fibrosis in a rat model of cirrhosis and to elucidate the underlying mechanisms. Male Sprague Dawley rats were used as the model of cirrhosis in the present study. In the cirrhotic rats, the extent of fibrosis, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), heme oxygenase‑1 (HO‑1) protein expression, serum levels of nuclear factor (NF)‑κB, tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH‑PX), and the protein expression levels of phosphorylated‑p38 mitogen‑activated protein kinase (MAPK) were all significantly increased. However, the serum malondialdehyde (MDA) activity and protein kinase B (Akt) protein expression were suppressed in cirrhotic rats compared with the sham (control) group. Compared with the cirrhotic group, administration of tanshinone IIA reduced the extent of fibrosis, levels of ALT and AST, HO‑1 protein expression, serum NF‑κB, TNF‑α, IL‑1β and IL‑6 levels, and the activity of SOD, CAT and GSH‑PX. Furthermore, administration of tanshinone IIA significantly increased the inhibition of the serum MDA activity and the Akt protein expression in cirrhotic rats compared with those in the cirrhotic group. The protective effect of tanshinone IIA suppresses fibrosis in a rat model of cirrhosis, and reduces inflammation and oxidative stress, via the HO‑1, Akt and p38 MAPK signaling pathway.
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