ArticleJournal of dental research2016
Levels of Candidate Periodontal Pathogens in Subgingival Biofilm.
Article in Journal of dental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of the Oral Microbiome in Periodontal Disease: A Systematic Review of Microbial Associations and Therapeutic Implications.Current microbiology · 2025Pooled it
- Trial
- Arginine metabolism as a mutualistic strategy in the interaction between Porphyromonas gingivalis and Filifactor alocis.Nature communications · 2026Article
- Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study.Journal of clinical periodontology · 2026Article
- Longitudinal dynamics and site-specific recovery of the human respiratory microbiome following smoking cessation.Respiratory research · 2026Article
- The Subgingival Host-Microbial Landscape in Mothers With Periodontitis and Their At-Risk Offspring.Journal of clinical periodontology · 2026Article
- Unveiling potential driver taxa in subgingival plaque and their roles in mediating periodontitis progression.Journal of oral microbiology · 2026Article
- Integration of periodontal pathogens and inflammatory mediators in saliva as biomarkers for periodontitis.Frontiers in cellular and infection microbiology · 2026Article
- Characterization of subgingival plaque microbiota in patients with severe periodontitis using full-length 16S rRNA gene sequencing.Scientific reports · 2025Article
- Closed genome sequence ofMicrobiology resource announcements · 2025Article
- hTAS2R38 polymorphisms modulate oral microbiota and influence the prevalence and treatment outcome of halitosis.Microbiome · 2025Article
- Article
- Evaluation of A. actinomycetemcomitans and P. gingivalis from the mouth of patients irradiated in the head and neck region: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Association ofDentistry journal · 2024Article
- Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus.Scientific reports · 2024Article
- Microbiome of diseased and healthy implants-a comprehensive microbial data analysis.Frontiers in cellular and infection microbiology · 2024Article
- Associations between Host Genetic Variants and Subgingival Microbiota in Patients with the Metabolic Syndrome.International journal of molecular sciences · 2023Article
- Selenomonas sputigena acts as a pathobiont mediating spatial structure and biofilm virulence in early childhood caries.Nature communications · 2023Article
- [Profiles and differences of submucosal microbial in peri-implantitis and health implants: A cross-sectional study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- qPCR Detection and Quantification ofPathogens (Basel, Switzerland) · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In recent years, several new periodontal taxa have been associated with the etiology of periodontitis. A recent systematic review provides further support for the pathogenic role of 17 species/phylotypes. Thus, the aim of this study was to assess the prevalence and levels of these species in subjects with generalized chronic periodontitis (GChP; n = 30), generalized aggressive periodontitis (GAgP; n = 30), and periodontal health (PH; n = 30). All subjects underwent clinical and microbiological assessment. Nine subgingival plaque samples were collected from each subject and analyzed for their content of 20 bacterial species/phylotypes through the RNA-oligonucleotide quantification technique. Subjects from the GChP and GAgP groups presented the highest mean values for all clinical parameters in comparison with the PH group (P < 0.05). Subjects with GChP and GAgP showed significantly higher mean levels of Bacteroidetes sp. human oral taxon (HOT) 274, Fretibacterium sp. HOT 360, and TM7 sp. HOT 356 phylotypes, as well as higher mean levels of Filifactor alocis, Fretibacterium fastidiosum, Porphyromonas gingivalis, Tannerella forsythia, and Selenomonas sputigena species than PH subjects (P < 0.05). GAgP subjects presented higher mean levels of TM7 sp. HOT 356 and F. alocis than GChP subjects (P < 0.05). A significantly higher mean prevalence of Bacteroidales sp. HOT 274, Desulfobulbus sp. HOT 041, Fretibacterium sp. HOT 360, and Fretibacterium sp. HOT 362 was found in subjects with GChP and GAgP than in PH subjects. Mean levels of P. gingivalis (r = 0.68), T. forsythia (r = 0.62), F. alocis (r = 0.51, P = 0.001), and Fretibacterium sp. HOT 360 (r = 0.41) were correlated with pocket depth (P < 0.001). In conclusion, Bacteroidales sp. HOT 274, Desulfobulbus sp. HOT 041, Fretibacterium sp. HOT 360, Fretibacterium sp. HOT 362, and TM7 sp. HOT 356 phylotypes, in addition to F. alocis, F. fastidiosum, and S. sputigena, seem to be associated with periodontitis, and their role in periodontal pathogenesis should be further investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.