ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2017
Effects of hemarthrosis on cartilage and synovium in rabbits.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway.Journal of orthopaedic translation · 2025Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo provide experimental basis for clinic treatment by observing the effects of simple acute hematoma on cartilage and synovium, and improvement of hyaluronic acid (HA) on the damage.
methodsTwenty-four New Zealand white rabbits were randomly divided 3 groups according to killed time: hematoma group, HA group and control group. These rabbits were killed at 4 days, 2, 4 and 8 weeks, respectively.
resultsKnee articular cartilage and synovium were obtained to detect histology, histochemistry and chondroitin proteoglycans (PG). Morphologies of cartilage and synovium in the control group were normal, while cartilage cells were detected hyperplasia of activation and each layer was disorganized in hematoma groups with 4 days and 2 weeks. Compared to the control group, concentrations of PG in 4 days and 2 weeks groups were significantly reduced (p < 0.05), while no significant difference was detected between 4 weeks group and the control group. Morphology was recovered normal in 8 weeks. Compared to hematoma group, morphology and histochemistry were improved in HA group at each time frame.
conclusionsSimple acute hematoma can lead to temporary change of morphology and biochemistry. Application of HA can reduce damage of hemarthrosis on cartilaginous and shorten the cartilage recovery time.
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