Evidence map›Paper›PMID 26936108›Full record

Trial reportScientific reports2016

Prevalence, incidence estimations, and risk factors of Toxoplasma gondii infection in Germany: a representative, cross-sectional, serological study.

Hendrik Wilking, Michael Thamm, Klaus Stark, Toni Aebischer, Frank Seeber

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 6 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 224 citations in OpenAlex.

  1. Systematic review and modelling ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Pooled it
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  7. Article
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  10. Evolution ofJournal of parasitology research · 2026
    Review
  11. Frontiers in psychiatry · 2026
    Article
  12. HumanMicroorganisms · 2025
    Article
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  16. Exposure of Eurasian blackbird (International journal for parasitology. Parasites and wildlife · 2025
    Article
  17. Seroprevalence and risk factors forParasite epidemiology and control · 2025
    Review
  18. bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hendrik WilkingUnit for Gastrointestinal Infections, Zoonoses and Tropical Infections, Robert Koch Institute, 13353 Berlin, Germany.
Michael ThammCentral Epidemiological Laboratory, Robert Koch Institute, 13302 Berlin, Germany.
Klaus StarkUnit for Gastrointestinal Infections, Zoonoses and Tropical Infections, Robert Koch Institute, 13353 Berlin, Germany.
Toni AebischerUnit for Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, 13353 Berlin, Germany.
Frank SeeberUnit for Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, 13353 Berlin, Germany.
Robert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Representative data on the extent of endemicity, burden, and risk of human toxoplasmosis are scarce. We assessed the prevalence and determinants of seropositivity of Toxoplasma gondii among adult participants of a nationwide representative cross-sectional survey in Germany. Sera collected from a representative cohort of adults (age 18-79; n = 6,663) in Germany were tested for anti-T. gondii IgG antibodies. Interview-derived data were used to evaluate associated factors. Multivariable logistic regression was applied using sampling weights and accounting for survey design cluster effects. Seroprevalence increased from 20% (95%-CI:17-23%) in the 18-29 age group to 77% (95%-CI:73-81%) in the 70-79 age group. Male gender, keeping cats and BMI ≥30 were independent risk factors for seropositivity, while being vegetarian and high socio-economic status were negatively associated. Based on these data, we estimate 1.1% of adults and 1.3% of women aged 18-49 to seroconvert each year. This implies 6,393 seroconversions annually during pregnancies. We conclude that T. gondii infection in Germany is highly prevalent and that eating habits (consuming raw meat) appear to be of high epidemiological relevance. High numbers of seroconversions during pregnancies pose substantial risks for unborn children. Efforts to raise awareness of toxoplasmosis in public health programs targeting to T. gondii transmission control are therefore strongly advocated.

Indexed as

Antibodies, ProtozoanImmunoglobulin GToxoplasmaToxoplasmosisAdultAgedAnimalsCatsFemaleGermanyHumansMaleMiddle AgedRisk FactorsSeroepidemiologic StudiesAntibodies, ProtozoanImmunoglobulin G

Identifiers

PMID26936108
PMCPMC4776094
OpenAlexW2291980640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.