ArticleBJOG : an international journal of obstetrics and gynaecology2016
Influence of fetal blood flow redistribution on fetal and childhood growth and fat distribution: the Generation R Study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Retinal Vascular Imaging Application in Women's Reproductive Health: Clinical Implications and Future Directions.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Associations of maternal metabolic profile with placental and fetal cerebral and cardiac hemodynamics.European journal of obstetrics, gynecology, and reproductive biology · 2021Article
- Article
- Cannabis Use in Pregnant and Breastfeeding Women: Behavioral and Neurobiological Consequences.Frontiers in psychiatry · 2020Review
- The Generation R Study: design and cohort update 2017.European journal of epidemiology · 2016Article
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6 authors.
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Abstract
objectiveA suboptimal intrauterine environment leads to fetal blood flow redistribution and fetal growth restriction. Not much is known about childhood growth consequences. We examined the associations of fetal blood flow redistribution with birth outcomes, and repeatedly measured fetal and childhood growth and fat mass measures.
designProspective cohort study.
settingPopulation-based. POPULATION: One thousand one hundred and ninety-five pregnant women and their children.
methodsWe measured umbilical and cerebral artery blood flow at a gestational age of 30.3 weeks (95% range, 28.5-32.6 weeks). A higher umbilical/cerebral (U/C) pulsatility index ratio is an indicator of preferential blood flow to the brain cerebral circulation at the expense of the lower body parts.
main outcome measuresFetal and childhood growth were repeatedly measured from the third trimester until childhood. We measured the total body fat mass, lean fat mass and android/gynoid fat mass ratio by dual-energy X-ray absorptiometry and preperitoneal fat by ultrasound at 6 years.
resultsA higher fetal U/C ratio was associated with increased risks of preterm birth and small size for gestational age at birth [odds ratios, 1.41 (95% confidence interval, 1.08-1.85) and 1.63 (95% confidence interval, 1.21-2.19), respectively, per SDS increase in U/C ratio]. Longitudinal growth analyses showed that a higher fetal U/C ratio was associated with persistently lower head circumference, length and weight from third trimester fetal life until childhood (all P < 0.05). The fetal U/C ratio was not associated with total body and abdominal fat measures at 6 years.
conclusionOur results suggest that fetal blood flow redistribution affects fetal development and has persistent consequences for childhood growth. TWEETABLE ABSTRACT: Fetal blood flow redistribution affects fetal development and has persistent consequences for childhood growth.
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