Trial reportJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2016
Thin-film optical notch filter spectacle coatings for the treatment of migraine and photophobia.
Trial report in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Earmuff and eye mask in the treatment of acute primary headache in emergency department: a randomized controlled open label study.BMC emergency medicine · 2025Trial
- Impact of Neurolens Use on the Quality of Life in Individuals With Headaches: A Randomized Double-Masked, Cross-Over Clinical Trial.Translational vision science & technology · 2024Trial
- Effects of Green Color Exposure on Stress, Anxiety, and Pain during Peripheral Intravenous Cannulation in Dental Patients Requiring Sedation.International journal of environmental research and public health · 2021Trial
- Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial.Cephalalgia : an international journal of headache · 2021Trial
- Neuropsychological influences on visual photosensitivity and its treatment in traumatic brain injury.BMJ open ophthalmology · 2026Article
- Light Filtering Lenses and Visual Photosensitivity in Individuals With Traumatic Brain Injury.Investigative ophthalmology & visual science · 2026Article
- An Overview of the Therapeutic Applications of Tinted Lenses Spectacles.Korean journal of ophthalmology : KJO · 2025Review
- Influence of next-generation artificial intelligence on headache research, diagnosis and treatment: the junior editorial board members' vision - part 1.The journal of headache and pain · 2024Review
- FL-41 Tint Reduces Activation of Neural Pathways of Photophobia in Patients with Chronic Ocular Pain.American journal of ophthalmology · 2024Article
- Evaluating the Potential of Green Light Exposure on Nociception-A Mini Review.CNS & neurological disorders drug targets · 2024Review
- Customized designed notch filters and applied effects on glare and contrast sensitivity in patients with dry eye syndrome.International ophthalmology · 2023Article
- Blue Light-Ocular and Systemic Damaging Effects: A Narrative Review.International journal of molecular sciences · 2023Review
- Prophylactic Treatment for Patients with Migraine Using Blue Cut for Night Glass.Internal medicine (Tokyo, Japan) · 2023Article
- Case Report: Green Light Exposure Relieves Chronic Headache Pain in a Colorblind Patient.Clinical medicine insights. Case reports · 2022Article
- Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation.The journal of pain · 2021Article
- Visual snow syndrome: evolving neuro-optometric considerations in concussion/mild traumatic brain injury.Concussion (London, England) · 2021Article
- Future directions in neuro-optometry.Concussion (London, England) · 2020Article
- Visual and non-visual properties of filters manipulating short-wavelength light.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2019Article
- Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light.The journal of pain · 2019Article
- Current understanding of photophobia, visual networks and headaches.Cephalalgia : an international journal of headache · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Previous evidence suggests optical treatments hold promise for treating migraine and photophobia. We designed an optical notch filter, centered at 480nm to reduce direct stimulation of intrinsically photosensitive retinal ganglion cells. We used thin-film technology to integrate the filter into spectacle lenses. Our objective was to determine if an optical notch filter, designed to attenuate activity of intrinsically photosensitive retinal ganglion cells, could reduce headache impact in chronic migraine subjects. For this randomized, double-masked study, our primary endpoint was the Headache Impact Test (HIT-6; GlaxoSmithKline, Brentford, Middlesex, UK). We developed two filters: the therapeutic filter blocked visible light at 480nm; a 620nm filter was designed as a sham. Participants were asked to wear lenses with one of the filters for 2weeks; after 2weeks when no lenses were worn, they wore lenses with the other filter for 2weeks. Of 48 subjects, 37 completed the study. Wearing either the 480 or 620nm lenses resulted in clinically and statistically significant HIT-6 reductions. However, there was no significant difference when comparing overall effect of the 480 and 620nm lenses. Although the 620nm filter was designed as a sham intervention, research published following the trial indicated that melanopsin, the photopigment in intrinsically photosensitive retinal ganglion cells, is bi-stable. This molecular property may explain the unexpected efficacy of the 620nm filter. These preliminary findings indicate that lenses outfitted with a thin-film optical notch filter may be useful in treating chronic migraine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.