ArticleNature reviews. Rheumatology2016
Connective tissue diseases: Mitochondria drive NETosis and inflammation in SLE.
Article in Nature reviews. Rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- SodA promotes immune evasion ofMicrobiology spectrum · 2026Article
- Pathophysiological Role of Neutrophil Extracellular Traps in Diet-Induced Obesity and Metabolic Syndrome in Animal Models.Nutrients · 2025Review
- Parvovirus B19 Infection Is Associated with the Formation of Neutrophil Extracellular Traps and Thrombosis: A Possible Linkage of the VP1 Unique Region.International journal of molecular sciences · 2024Article
- Mesenchymal stem cell-derived extracellular vesicles accelerate diabetic wound healing by inhibiting NET-induced ferroptosis of endothelial cells.International journal of biological sciences · 2024Article
- Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy.Frontiers in immunology · 2023Review
- MSC-EVs transferring mitochondria and related components: A new hope for the treatment of kidney disease.Frontiers in immunology · 2022Review
- Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis.Journal for immunotherapy of cancer · 2021Article
- Identification of sequence polymorphisms in the mitochondrial deoxyribonucleic acid displacement-loop region as risk factors for systemic lupus erythematosus.Archives of rheumatology · 2021Article
- The role of neutrophil death in chronic inflammation and cancer.Cell death discovery · 2020Review
- Precipitating anti-dsDNA peptide repertoires in lupus.Clinical and experimental immunology · 2018Article
- T cells and autoimmune kidney disease.Nature reviews. Nephrology · 2017Review
- Neutrophil Extracellular Traps, Antiphospholipid Antibodies and Treatment.Antibodies (Basel, Switzerland) · 2017Review
- New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondria are the powerhouses of the cell, providing energy through oxidative respiration. Possibly owing to their similarities with bacteria, however, mitochondria extruded from cells promote inflammation. New research demonstrates that in systemic lupus erythematosus, mitochondrial respiration is critical in neutrophil extracellular trap formation, and that mitochondria released by neutrophils induce inflammatory cytokine production.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.