Trial reportObesity (Silver Spring, Md.)2016
Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations.
Trial report in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04671186 (Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease), which is not on this map. Cited by 41 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Probiotics in Treatment of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Patients by Assessing With Fibroscan
Who cites it
41 citing papers in PubMed, 6 syntheses or guidelines pooled it, 74 citations in OpenAlex.
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- Systematic review of electronically delivered behavioral obesity prevention interventions targeting men.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
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- Telemedicine-Based Health Coaching Is Effective for Inducing Weight Loss and Improving Metabolic Markers.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2019Trial
- Trial
- Effects of aerobic training with and without weight loss on insulin sensitivity and lipids.PloS one · 2018Trial
- Exercise-induced compensation and C-reactive protein change in adults with elevated C-reactive protein: analysis of a randomised controlled trial.European journal of applied physiology · 2026Article
- Outcomes and Predictors of Success for Very Low Calorie Diets in an Australian Publicly Funded Bariatric Medicine Service.Obesity science & practice · 2026Article
- Role of Physical Activity in Obesity Treatment and Cardiometabolic Health: A Scientific Statement From the American Heart Association.Circulation · 2026Review
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- Optimising metformin use in polycystic ovary syndrome (MET-PCOS): study protocol for a double-blind randomised controlled trial.BMJ open · 2026Article
- Adherence to heart rate-based intensity parameters predicts cardiovascular response to 12-weeks of aerobic cycling training in sedentary older adults.Preventive medicine reports · 2026Article
- Lesions involving the insula are associated with reduced appetite and weight loss.Brain communications · 2026Article
- Machine learning algorithms for predicting glycemic control and weight loss outcomes in GLP-1 receptor agonist users.Frontiers in artificial intelligence · 2026Article
- Type 2 diabetes mediated heart failure: focus on early recognition and clinical strategies.Frontiers in endocrinology · 2025Review
- The Role of Cardiac Rehabilitation in Promoting Lifestyle Modification Among Cardiovascular Patients: A Nationwide Cohort Study.Healthcare (Basel, Switzerland) · 2024Article
- Article
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo determine response rates for clinically significant weight loss (CWL) following different aerobic exercise training amounts and whether enhanced cardiometabolic adaptations are observed with CWL compared to modest weight loss (MWL) or neither.
methodsParticipants (N = 330) performed 6 months of aerobic training at 4 kcal per kilogram per week (KKW), 8 KKW, or 12 KKW (50%, 100%, and 150% of recommended levels respectively). Weight loss was categorized as CWL (≥5%) or MWL (3.0% to 4.9%) or neither.
resultsThe CWL response rate was greater in the 8 KKW group (20.2%, CI: 13.0% to 27.5%) compared to 4 KKW (10.3%, CI: 4.6% to 16.0%), but not compared to the 12 KKW group (14.6%, CI: 7.6% to 21.6%). Reductions in HOMA-IR were observed in participants with CWL (-0.60, CI: -0.98 to -0.22) and with MWL (-0.48, CI: -0.87 to -0.10), but not those who achieved neither (-0.06, CI -0.22 to 0.10). No changes between groups were observed for cholesterol, fitness, or blood pressure.
conclusionsLow response rates for CWL were observed following training, even at levels above recommended levels. Achieving MWL with exercise may represent a reasonable initial weight loss target since the improvement in insulin resistance with MWL is similar to what is achieved with CWL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.