Evidence map›Paper›PMID 26935101›Full record

ArticleDisease models & mechanisms2016

Fruit flies on the front line: the translational impact of Drosophila.

Norbert Perrimon, Nancy M Bonini, Paraminder Dhillon

Abstract readEditorial
In one paragraph

Article in Disease models & mechanisms, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Diversity ofFrontiers in cell and developmental biology · 2025
    Article
  3. Article
  4. Article
  5. Progressive degeneration in a newResearch square · 2023
    Article
  6. Towards early detection of neurodegenerative diseases: A gut feeling.Frontiers in cell and developmental biology · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Frontiers in physiology · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Neural plasticity · 2017
    Review
  20. AyurvedicJournal of biosciences · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Norbert PerrimonDepartment of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA perrimon@receptor.med.harvard.edu nbonini@sas.upenn.edu.
Nancy M BoniniBiology Department, University of Pennsylvania, Philadelphia, PA 19104, USA perrimon@receptor.med.harvard.edu nbonini@sas.upenn.edu.
Paraminder DhillonDisease Models & Mechanisms, The Company of Biologists, Bidder Building, Station Road, Histon, Cambridge, CB24 9LF, UK.

Funding

Epigenetic Changes associated with Neurodegenerative DiseasesR01NS078283 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BERGER, SHELLEY L, BONINI, NANCY M · 2012 to 2016
$3.3M
Ataxin-2 as a genetic risk factor for ALS: New insights into neurodegenerationR01NS073660 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BONINI, NANCY M, GITLER, AARON D. · 2011 to 2015
$1.7M
NINDS NIH HHS R01 NS073660NINDS NIH HHS R01 NS078283
6 · The paper itself

Abstract

Drosophila melanogaster has been adopted as one of the most-used model systems since it was first introduced by Thomas Morgan for the study of heredity in the early 20th century. Its experimental tractability and similarity of its biological pathways to those of humans have placed the model at the forefront of research into human development and disease. With the ongoing accumulation of genetic tools and assays, the fly community has at its fingertips the resources to generate diverse Drosophila disease models for the study of genes and pathways involved in a wide range of disorders. In recent years, the fly has also been used successfully for drug screening. In this Editorial, we introduce a Special Collection of reviews, interviews and original research articles that highlight some of the many ways that Drosophila has made, and continues to make, an impact on basic biological insights and translational science.

Indexed as

Translational Research, BiomedicalAnimalsCardiovascular DiseasesDrosophila melanogasterHumansNerve DegenerationCancerDrosophilaGenomicsNeurodegeneration

Identifiers

PMID26935101
PMCPMC4833334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.