Evidence map›Paper›PMID 26934855›Full record

ReviewMolecular medicine reports2016

DNA methylation in endometriosis (Review).

Ourania Koukoura, Stavros Sifakis, Demetrios A Spandidos

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Expression ofInternational journal of molecular sciences · 2023
    Pooled it
  2. Review
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  5. Article
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  10. Article
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  12. Review
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  15. Article
  16. Review
  17. Article
  18. The roles of chromatin regulatory factors in endometriosis.Journal of assisted reproduction and genetics · 2024
    Review
  19. Review
  20. The Impact of Endometriosis on Pregnancy.Journal of personalized medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ourania KoukouraDepartment of Obstetrics and Gynecology, University Hospital of Larissa, Larissa 41500, Greece.
Stavros SifakisDepartment of Obstetrics and Gynecology, University Hospital of Heraklion, Heraklion 71003, Greece.
Demetrios A SpandidosLaboratory of Clinical Virology, University of Crete Medical School, Heraklion 71409, Greece.
University Hospital of Heraklion · GRUniversity Hospital of Larissa · GRUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis is defined by the presence and growth of functional endometrial tissue, outside the uterine cavity, primarily in the ovaries, pelvic peritoneum and rectovaginal septum. Although it is a benign disease, it presents with malignant characteristics, such as invasion to surrounding tissues, metastasis to distant locations and recurrence following treatment. Accumulating evidence suggests that various epigenetic aberrations may play an essential role in the pathogenesis of endometriosis. Aberrant DNA methylation represents a possible mechanism repsonsible for this disease, linking gene expression alterations observed in endometriosis with hormonal and environmental factors. Several lines of evidence indicate that endometriosis may partially be due to selective epigenetic deregulations influenced by extrinsic factors. Previous studies have shed light into the epigenetic component of endometriosis, reporting variations in the epigenetic patterns of genes known to be involved in the aberrant hormonal, immunologic and inflammatory status of endometriosis. Although recent studies, utilizing advanced molecular techniques, have allowed us to further elucidate the possible association of DNA methylation with altered gene expression, whether these molecular changes represent the cause or merely the consequence of the disease is a question which remains to be answered. This review provides an overview of the current literature on the role of DNA methylation in the pathophysiology and malignant evolution of endometriosis. We also provide insight into the mechanisms through which DNA methylation-modifying agents may be the next step in the research of the pharmaceutical treatment of endometriosis.

Indexed as

DNA MethylationEpigenesis, GeneticGene Expression RegulationAromataseCell Transformation, NeoplasticDNA (Cytosine-5-)-MethyltransferasesEndometriosisFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHomeobox A10 ProteinsHomeodomain ProteinsHumansMolecular Targeted TherapyReceptors, EstrogenReceptors, ProgesteroneAromataseDNA (Cytosine-5-)-MethyltransferasesHomeobox A10 ProteinsHomeodomain ProteinsHOXA10 protein, humanReceptors, EstrogenReceptors, ProgesteroneSteroidogenic Factor 1

Identifiers

PMID26934855
PMCPMC4805102
OpenAlexW2278616750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.