ArticleScientific reports2016
Topographic Cues Reveal Two Distinct Spreading Mechanisms in Blood Platelets.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Early Platelet Dysfunction in Sepsis: An ICU Pilot Study.Pathogens (Basel, Switzerland) · 2026Observational
- Force generation in human blood platelets by filamentous actomyosin structures.Biophysical journal · 2023Article
- A novel association between platelet filamin A and soluble N-ethylmaleimide sensitive factor attachment proteins regulates granule secretion.Research and practice in thrombosis and haemostasis · 2023Article
- Improving Bioactive Characteristics of Small Diameter Polytetrafluoroethylene Stent Grafts by Electrospinning: A Comparative Hemocompatibility Study.Bioengineering (Basel, Switzerland) · 2023Article
- Regulation of Mesenchymal Stem Cell Morphology Using Hydrogel Substrates with Tunable Topography and Photoswitchable Stiffness.Polymers · 2022Article
- Nanofiber Topographies Enhance Platelet-Fibrinogen Scaffold Interactions.Advanced healthcare materials · 2022Article
- Fishing for answers to hemostatic and thrombotic disease: Genome editing in zebrafish.Research and practice in thrombosis and haemostasis · 2022Review
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- Article
- Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels.International journal of molecular sciences · 2020Article
- Differential dynamics of early stages of platelet adhesion and spreading on collagen IV- and fibrinogen-coated surfaces.F1000Research · 2020Article
- Fatal dysfunction and disintegration of thrombin-stimulated platelets.Haematologica · 2019Article
- Differential Modulation of Platelet Adhesion and Spreading by Adhesive Ligand Density.Nano letters · 2019Article
- Wdr-1 is essential for F-actin interaction with focal adhesions in platelets.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2018Article
- Morphometric analysis of spread platelets identifies integrin αScientific reports · 2018Article
- Thrombin-induced cytoskeleton dynamics in spread human platelets observed with fast scanning ion conductance microscopy.Scientific reports · 2017Article
- Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs.Biomolecules & therapeutics · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood platelets are instrumental in blood clotting and are thus heavily involved in early wound closure. After adhering to a substrate they spread by forming protrusions like lamellipodia and filopodia. However, the interaction of these protrusions with the physical environment of platelets while spreading is not fully understood. Here we dynamically image platelets during this spreading process and compare their behavior on smooth and on structured substrates. In particular we analyze the temporal evolution of the spread area, the cell morphology and the dynamics of individual filopodia. Interestingly, the topographic cues enable us to distinguish two spreading mechanisms, one that is based on numerous persistent filopodia and one that rather involves lamellipodia. Filopodia-driven spreading coincides with a strong response of platelet morphology to the substrate topography during spreading, whereas lamellipodia-driven spreading does not. Thus, we quantify different degrees of filopodia formation in platelets and the influence of filopodia in spreading on structured substrates.
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