Evidence map›Paper›PMID 26934447›Full record

ArticleOncotarget2016

Significance of the NOR1-FOXA1/HDAC2-Slug regulatory network in epithelial-mesenchymal transition of tumor cells.

Wei Wang, Mei Yi, Shengnan Chen, Junjun Li, Guo Li, Jianbo Yang, Pan Zheng, Haijing Zhang, Wei Xiong, James B McCarthy and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  17. OncoTargets and therapy · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Wei WangHunan Provincial Cancer Hospital and Cancer Hospital Affiliated to Xiangya Medical School, The Central South University, Changsha, Hunan 410013, China.
Mei YiDepartment of Dermatology, Xiangya Hospital, The Central South University, Changsha, 410008, Hunan, China.
Shengnan ChenHunan Provincial Cancer Hospital and Cancer Hospital Affiliated to Xiangya Medical School, The Central South University, Changsha, Hunan 410013, China.
Junjun LiCancer Research Institute, Xiangya School of Medicine, The Central South University, Changsha 410078, China.
Guo LiDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, The Central South University, Changsha, 410008, Hunan, China.
Jianbo YangDepartment of Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Pan ZhengCancer Research Institute, Xiangya School of Medicine, The Central South University, Changsha 410078, China.
Haijing ZhangCancer Research Institute, Xiangya School of Medicine, The Central South University, Changsha 410078, China.
Wei XiongCancer Research Institute, Xiangya School of Medicine, The Central South University, Changsha 410078, China.
James B McCarthyDepartment of Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Guiyuan LiCancer Research Institute, Xiangya School of Medicine, The Central South University, Changsha 410078, China.
Xiaoling LiCancer Research Institute, Xiangya School of Medicine, The Central South University, Changsha 410078, China.
Bo XiangHunan Provincial Cancer Hospital and Cancer Hospital Affiliated to Xiangya Medical School, The Central South University, Changsha, Hunan 410013, China.
Central South University · CNHunan Cancer Hospital · CNUniversity of Minnesota · USXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epithelial-mesenchymal transition (EMT) process is believed to play a crucial role in nasopharyngeal carcinoma (NPC) progression, a squamous cell carcinoma of the head and neck with the tendency to metastasize early. At present, much attention has been given to the inducer of EMT involved in NPC progression, while antagonists have been less intensively characterized. In this study, unbiased analysis of EMT-associated gene expression patterns was performed using data mining of global gene expression profiles derived from NPC samples, leading to the successful identification of NOR1, FOXA1, and Slug, all of which showed aberrant expression during NPC progression. The effect of tumor suppressor NOR1 on Slug-induced NPC cells during the EMT process was investigated by use of ectopic expression and RNA interference methods. The molecular mechanisms underlying the tumor-suppressing effect of NOR1 on Slug-induced EMT were thought to be dependent on the cooperation of NOR1 with the FOXA1-HDAC2 complex. We also showed that FOXA1 and HDAC2 bind the slug promoter and directly repress its transcription. Our data revealed a previously unrecognized role of the NOR1-FOXA1/HDAC2-Slug network in the regulation of the EMT process and aggressiveness of NPC.

Indexed as

AdultAgedCarcinomaCell Line, TumorEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-alphaHistone Deacetylase 2HumansMaleMembrane Transport ProteinsMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsSignal TransductionFOXA1 protein, humanHDAC2 protein, humanHepatocyte Nuclear Factor 3-alphaHistone Deacetylase 2Membrane Transport ProteinsOSCP1 protein, humanSNAI1 protein, humanSnail Family Transcription Factorsepithelial-mesenchymal transitionFOXA1nasopharyngeal carcinomaNOR1

Identifiers

PMID26934447
PMCPMC4941348
OpenAlexW2297705984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.