ArticleEndocrinology2016
BPA Directly Decreases GnRH Neuronal Activity via Noncanonical Pathway.
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of Nonylphenol on the Secretions of Catecholamines, Gonadotropin-Releasing Hormone (GnRH) and Kisspeptin from Short-Term Incubated Rat Hypothalamus.Development & reproduction · 2025Article
- Analysis of bisphenol A-modulated expression of hypothalamic thyroid, estrogen, and peroxisome proliferator-activated receptors and concurrent mitochondrial dynamics following short-term exposure in mice.Current research in toxicology · 2025Article
- Interaction of GPER-1 with the endocrine signaling axis in breast cancer.Frontiers in endocrinology · 2025Review
- Endocrine-Disrupting Chemicals, Hypothalamic Inflammation and Reproductive Outcomes: A Review of the Literature.International journal of molecular sciences · 2024Review
- Article
- Effect of bisphenol A on the neurological system: a review update.Archives of toxicology · 2024Review
- Article
- Probiotic Administration Mitigates Bisphenol A Reproductive Toxicity in Zebrafish.International journal of molecular sciences · 2021Article
- Modulation of folliculogenesis in adult laying chickens by bisphenol A and bisphenol S: Perspectives on ovarian morphology and gene expression.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell.The Journal of comparative neurology · 2021Article
- Cellular and molecular features of EDC exposure: consequences for the GnRH network.Nature reviews. Endocrinology · 2021Review
- Bisphenols and Leydig Cell Development and Function.Frontiers in endocrinology · 2020Review
- Bisphenol A Activates Calcium Influx in Immortalized GnRH Neurons.International journal of molecular sciences · 2019Article
- Neuro-toxic and Reproductive Effects of BPA.Current neuropharmacology · 2019Review
- Modulation of Gonadotropin-Releasing Hormone Neuron Activity and Secretion in Mice by Non-peptide Neurotransmitters, Gasotransmitters, and Gliotransmitters.Frontiers in endocrinology · 2019Review
- Perinatal BPA exposure and reproductive axis function in CD-1 mice.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation.Scientific reports · 2018Article
- Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure.Metabolic brain disease · 2017Article
- Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.International journal of molecular sciences · 2016Review
- An Emerging Role of micro-RNA in the Effect of the Endocrine Disruptors.Frontiers in neuroscience · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Peripheral feedback of gonadal estrogen to the hypothalamus is critical for reproduction. Bisphenol A (BPA), an environmental pollutant with estrogenic actions, can disrupt this feedback and lead to infertility in both humans and animals. GnRH neurons are essential for reproduction, serving as an important link between brain, pituitary, and gonads. Because GnRH neurons express several receptors that bind estrogen, they are potential targets for endocrine disruptors. However, to date, direct effects of BPA on GnRH neurons have not been shown. This study investigated the effects of BPA on GnRH neuronal activity using an explant model in which large numbers of primary GnRH neurons are maintained and express many of the receptors found in vivo. Because oscillations in intracellular calcium have been shown to correlate with electrical activity in GnRH neurons, calcium imaging was used to assay the effects of BPA. Exposure to 50μM BPA significantly decreased GnRH calcium activity. Blockage of γ-aminobutyric acid ergic and glutamatergic input did not abrogate the inhibitory BPA effect, suggesting direct regulation of GnRH neurons by BPA. In addition to estrogen receptor-β, single-cell RT-PCR analysis confirmed that GnRH neurons express G protein-coupled receptor 30 (G protein-coupled estrogen receptor 1) and estrogen-related receptor-γ, all potential targets for BPA. Perturbation studies of the signaling pathway revealed that the BPA-mediated inhibition of GnRH neuronal activity occurred independent of estrogen receptors, GPER, or estrogen-related receptor-γ, via a noncanonical pathway. These results provide the first evidence of a direct effect of BPA on GnRH neurons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.