Effect of Insulin Glargine Up-titration vs Insulin Degludec/Liraglutide on Glycated Hemoglobin Levels in Patients With Uncontrolled Type 2 Diabetes: The DUAL V Randomized Clinical Trial.

Ildiko Lingvay et al.PubMed ↗Publisher ↗

The primary results report of NCT01952145. Its numbers are set against the trial’s posted results below.

What the trial testedas reported · 557 people · 2016

Not counted

Probably lowered glycemic control

−0.59percentage points−0.74 to −0.45

As reported

difference −0.59 %, 95% CI −0.74 to −0.45

Not counted

Probably lowered hypoglycaemia

−57%−70% to −39%

Bigger than 9 in 10 on the map

As reported

IRR 0.43, 95% CI 0.30–0.61

Against the trial’s posted results

Same as the trial’s posted resultThis paper difference −0.59 (−0.74 to −0.45)Posted, primary outcome difference −0.59 (−0.74 to −0.45), p < 0.001Change From Baseline in HbA1c (Glycosylated Haemoglobin)

Two numbers in the abstract

the abstract, start to end

… estimated treatment difference [ETD], -0.59% [95% CI, -0.74% to -0.45%]), …

… 5.05 for glargine; estimated rate ratio, 0.43 [95% CI, 0.30 to …

← favours treatmentfavours comparator →

could be chance

Glycemic control

−0.59−0.74 to −0.45

Hypoglycaemia

IRR 0.430.30–0.61

GLP-1 receptor agonistsInsulinGlycemic controlHypoglycaemia

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The trial

NCT01952145phase 3557 enrolled2013this paper is its primary report