ArticlePloS one2016
Obstructive Sleep Apnoea Modulates Airway Inflammation and Remodelling in Severe Asthma.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Association of obstructive sleep apnea risk with allergic asthma: A systematic review and meta-analysis.Medicine · 2025Pooled it
- The relationship between obstructive sleep apnea and asthma severity and vice versa: a systematic review and meta-analysis.European journal of medical research · 2023Pooled it
- Interleukin-8 concentrations in obstructive sleep apnea syndrome: a systematic review and meta-analysis.Bioengineered · 2021Pooled it
- Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis.Scientific reports · 2017Pooled it
- Is obstructive sleep apnea a driver of cancer and chronic disease risk? A real-world analysis of over 3 million patients.BMC pulmonary medicine · 2026Article
- Overnight deep inspiration patterns in obstructive sleep apnea patients with and without asthma.Physiological reports · 2025Article
- Temporal Dynamics of Fractional Exhaled Nitric Oxide (FeNO) During CPAP Therapy in Obstructive Sleep Apnea: A Prospective Follow-Up Study.Nature and science of sleep · 2025Article
- Severe Asthma and Sleep Disorders: A Severe Asthma Network Italy (SANI) Registry Analysis.Journal of asthma and allergy · 2025Article
- A study on pulmonary function in children with obstructive sleep apnea hypopnea syndrome.Sleep & breathing = Schlaf & Atmung · 2024Article
- The prevalence of obstructive sleep apnea in Japanese asthma patients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications.Frontiers in allergy · 2024Review
- Asthma and hypertension: the role of airway inflammation.Frontiers in medicine · 2024Article
- Revisiting Asthma Obstructive Sleep Apnea Overlap: Current Knowledge and Future Needs.Journal of clinical medicine · 2023Review
- Chronic intermittent hypoxia increases airway hyperresponsiveness during house dust mites exposures in rats.Respiratory research · 2023Article
- Obese asthma phenotypes display distinct plasma biomarker profiles.Clinical and translational allergy · 2023Article
- Effects of obstructive sleep apnea hypopnea syndrome on postoperative complications in patients who undergo off-pump coronary artery bypass grafting.Sleep & breathing = Schlaf & Atmung · 2022Article
- Asthma Exacerbations and Glucagon-Like Peptide-1 Receptor Agonists: a Review of the Current Evidence.Pulmonary therapy · 2022Review
- Oropharyngeal obstruction and respiratory system compliance are linked to ventilatory control parameters in pediatric obstructive sleep apnea syndrome.Scientific reports · 2022Article
- The Association between Asthma and OSA in Children.Children (Basel, Switzerland) · 2022Article
- Overlaps between obstructive sleep apnoea and other respiratory diseases, including COPD, asthma and interstitial lung disease.Breathe (Sheffield, England) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnoea (OSA) is frequently observed in severe asthma but the causal link between the 2 diseases remains hypothetical. The role of OSA-related systemic and airway neutrophilic inflammation in asthma bronchial inflammation or remodelling has been rarely investigated. The aim of this study was to compare hallmarks of inflammation in induced sputum and features of airway remodelling in bronchial biopsies from adult patients with severe asthma with and without OSA. MATERIALS AND
methodsAn overnight polygraphy was performed in 55 patients referred for difficult-to-treat asthma, who complained of nocturnal respiratory symptoms, poor sleep quality or fatigue. We compared sputum analysis, reticular basement membrane (RBM) thickness, smooth muscle area, vascular density and inflammatory cell infiltration in bronchial biopsies.
resultsIn total, 27/55 patients (49%) had OSA diagnosed by overnight polygraphy. Despite a moderate increase in apnoea-hypopnoea index (AHI; 14.2 ± 1.6 event/h [5-35]), the proportion of sputum neutrophils was higher and that of macrophages lower in OSA than non-OSA patients, with higher levels of interleukin 8 and matrix metalloproteinase 9. The RBM was significantly thinner in OSA than non-OSA patients (5.8 ± 0.4 vs. 7.8 ± 0.4 μm, p<0.05). RBM thickness and OSA severity assessed by the AHI were negatively correlated (rho = -0.65, p<0.05). OSA and non-OSA patients did not differ in age, sex, BMI, lung function, asthma control findings or treatment.
conclusionMild OSA in patients with severe asthma is associated with increased proportion of neutrophils in sputum and changes in airway remodelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.