ArticlePLoS pathogens2016
Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease.Seminars in immunopathology · 2026Review
- Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt.Infection and immunity · 2023Article
- Newly recruited intraepithelial Ly6AImmunity · 2022Article
- VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection.Journal of virology · 2022Article
- The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection.PLoS pathogens · 2021Article
- Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome.Cell host & microbe · 2021Article
- Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases.Gastroenterology · 2021Review
- Adenovirus-Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes.Viruses · 2020Review
- Defensin-driven viral evolution.PLoS pathogens · 2020Article
- RP-HPLC-ESI-IT Mass Spectrometry Reveals Significant Variations of the Human Salivary Protein Profile Associated with Predominantly Antibody Deficiencies.Journal of clinical immunology · 2020Article
- Article
- Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host.FEBS letters · 2019Review
- Alpha-defensin 5 differentially modulates adenovirus vaccine vectors from different serotypes in vivo.PLoS pathogens · 2019Article
- Enteric viruses exploit the microbiota to promote infection.Current opinion in virology · 2019Review
- Origin and development of oligoadenylate synthetase immune system.BMC evolutionary biology · 2018Article
- Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre.The Journal of general virology · 2018Article
- Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.The Journal of clinical investigation · 2018Article
- Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice.The American journal of pathology · 2018Article
- Article
- Towards the Application of Human Defensins as Antivirals.Biomolecules & therapeutics · 2018Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
α-defensins are abundant antimicrobial peptides with broad, potent antibacterial, antifungal, and antiviral activities in vitro. Although their contribution to host defense against bacteria in vivo has been demonstrated, comparable studies of their antiviral activity in vivo are lacking. Using a mouse model deficient in activated α-defensins in the small intestine, we show that Paneth cell α-defensins protect mice from oral infection by a pathogenic virus, mouse adenovirus 1 (MAdV-1). Survival differences between mouse genotypes are lost upon parenteral MAdV-1 infection, strongly implicating a role for intestinal defenses in attenuating pathogenesis. Although differences in α-defensin expression impact the composition of the ileal commensal bacterial population, depletion studies using broad-spectrum antibiotics revealed no effect of the microbiota on α-defensin-dependent viral pathogenesis. Moreover, despite the sensitivity of MAdV-1 infection to α-defensin neutralization in cell culture, we observed no barrier effect due to Paneth cell α-defensin activation on the kinetics and magnitude of MAdV-1 dissemination to the brain. Rather, a protective neutralizing antibody response was delayed in the absence of α-defensins. This effect was specific to oral viral infection, because antibody responses to parenteral or mucosal ovalbumin exposure were not affected by α-defensin deficiency. Thus, α-defensins play an important role as adjuvants in antiviral immunity in vivo that is distinct from their direct antiviral activity observed in cell culture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.