Evidence map›Paper›PMID 26933744›Full record

ReviewCell chemical biology2016

DNA Charge Transport: from Chemical Principles to the Cell.

Anna R Arnold, Michael A Grodick, Jacqueline K Barton

Abstract readReview
In one paragraph

Review in Cell chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 162 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. From single step hops to emergent biological phenomena.Journal of inorganic biochemistry · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. The Avoidance of Purine Stretches by Cancer Mutations.International journal of molecular sciences · 2024
    Article
  11. Revised mechanism of hydroxyurea-induced cell cycle arrest and an improved alternative.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. The Influence of Oxidized Imino-Allantoin in the Presence ofInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anna R ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Michael A GrodickDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Jacqueline K BartonDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: jkbarton@caltech.edu.
California Institute of Technology · US

Funding

ELECTROCHEMICAL DNA-BASED SENSORSR01GM061077 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BARTON, JACQUELINE K · 2000 to 2017
$5.2M
METAL PROBES AND DRUG BINDING TO DNA CHANGE OF GRANTEE IR01GM033309 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BARTON, JACQUELINE K · 1985 to 2014
$3.2M
NIGMS NIH HHS R01 GM033309NIGMS NIH HHS R01 GM061077
6 · The paper itself

Abstract

The DNA double helix has captured the imagination of many, bringing it to the forefront of biological research. DNA has unique features that extend our interest into areas of chemistry, physics, material science, and engineering. Our laboratory has focused on studies of DNA charge transport (CT), wherein charges can efficiently travel long molecular distances through the DNA helix while maintaining an exquisite sensitivity to base pair π-stacking. Because DNA CT chemistry reports on the integrity of the DNA duplex, this property may be exploited to develop electrochemical devices to detect DNA lesions and DNA-binding proteins. Furthermore, studies now indicate that DNA CT may also be used in the cell by, for example, DNA repair proteins, as a cellular diagnostic, in order to scan the genome to localize efficiently to damage sites. In this review, we describe this evolution of DNA CT chemistry from the discovery of fundamental chemical principles to applications in diagnostic strategies and possible roles in biology.

Indexed as

ElectronsAnimalsDNADNA-Binding ProteinsDNA DamageDNA RepairElectrochemical TechniquesElectron TransportHumansModels, MolecularNucleic Acid ConformationOxidative StressPhotochemical ProcessesSignal TransductionDNADNA-Binding Proteins

Identifiers

PMID26933744
PMCPMC4803044
OpenAlexW2251721197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.