ArticleScience advances2016
Miniature high-throughput chemosensing of yield, ee, and absolute configuration from crude reaction mixtures.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Stereodynamic Helicenes for Chirality Sensing and Enantiomeric Assay through Diastereomeric Helical Enrichment.JACS Au · 2026Article
- Chiral Analysis for High-Throughput Reaction Screening: Recent Advances in Accelerating Asymmetric Catalysis Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Molecular Recognition and Chirality Sensing with Metallocene Dichloride Complexes.The Journal of organic chemistry · 2026Article
- High-ThroughputACS central science · 2025Article
- Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography.Angewandte Chemie (International ed. in English) · 2025Article
- Molecular Sensing of Chiral Carboxylic Acid Enantiomers Using CD Inductions in the Visible Light Region.The Journal of organic chemistry · 2025Article
- Rapid Enantiomeric Excess Measurements of Enantioisotopomers by Molecular Rotational Resonance Spectroscopy.Organic process research & development · 2023Article
- Optical deciphering of multinary chiral compound mixtures through organic reaction based chemometric chirality sensing.Nature communications · 2021Article
- A rapid and sensitive method for chiroptical sensing of α-amino acidsChemical science · 2020Article
- High-throughput assay for determining enantiomeric excess of chiral diols, amino alcohols, and amines and for direct asymmetric reaction screening.Nature protocols · 2020Article
- Absolute Configuration Assignment to Chiral Natural Products by Biphenyl Chiroptical Probes: The Case of the Phytotoxins Colletochlorin A and Agropyrenol.Journal of natural products · 2020Article
- Rapid Optical Determination of Enantiomeric Excess, Diastereomeric Excess, and Total Concentration Using Dynamic-Covalent Assemblies: A Demonstration Using 2-Aminocyclohexanol and Chemometrics.Journal of the American Chemical Society · 2019Article
- Click chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures.Nature communications · 2018Article
- Article
- The In Situ Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification.Current protocols in chemical biology · 2017Article
- A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.Chemical science · 2017Article
- A racemate-rules effect supramolecular polymer for ee determination of malic acid in the high ee region.Chemical communications (Cambridge, England) · 2016Article
- Chirality imprinting and direct asymmetric reaction screening using a stereodynamic Brønsted/Lewis acid receptor.Nature communications · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-throughput experimentation (HTE) has emerged as a widely used technology that accelerates discovery and optimization processes with parallel small-scale reaction setups. A high-throughput screening (HTS) method capable of comprehensive analysis of crude asymmetric reaction mixtures (eliminating product derivatization or isolation) would provide transformative impact by matching the pace of HTE. We report how spontaneous in situ construction of stereodynamic metal probes from readily available, inexpensive starting materials can be applied to chiroptical chemosensing of the total amount, enantiomeric excess (ee), and absolute configuration of a wide variety of amines, diamines, amino alcohols, amino acids, carboxylic acids, α-hydroxy acids, and diols. This advance and HTS potential are highlighted with the analysis of 1 mg of crude reaction mixtures of a catalytic asymmetric reaction. This operationally simple assay uses a robust mix-and-measure protocol, is amenable to microscale platforms and automation, and provides critical time efficiency and sustainability advantages over traditional serial methods.
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Registered trials
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