ArticleScience advances2016
Spontaneous structural transition and crystal formation in minimal supramolecular polymer model.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 75 citations in OpenAlex.
- Controlling Supramolecular Assembly through Peptide Chirality.ACS applied materials & interfaces · 2025Article
- Molecular Engineering of Recombinant Protein Hydrogels: Programmable Design and Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- Ordered Aggregates of Fmoc-Diphenylalanine at Alkaline pH as a Precursor of Fibril Formation and Peptide Gelation.The journal of physical chemistry. B · 2025Article
- Preparation, design, identification and application of self-assembly peptides from seafood: A review.Food chemistry: X · 2024Article
- Anion Effects on the Supramolecular Self-Assembly of Cationic Phenylalanine Derivatives.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Does Supramolecular Gelation Require an External Trigger?Gels (Basel, Switzerland) · 2022Article
- Modification of a Single Atom Affects the Physical Properties of Double Fluorinated Fmoc-Phe Derivatives.International journal of molecular sciences · 2021Article
- Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information.Frontiers in bioengineering and biotechnology · 2021Review
- Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Topochemical synthesis of different polymorphs of polymers as a paradigm for tuning properties of polymers.Nature communications · 2020Article
- Strategy to Identify Improved N-Terminal Modifications for Supramolecular Phenylalanine-Derived Hydrogelators.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Hierarchically oriented organization in supramolecular peptide crystals.Protein and peptide letters · 2019Article
- Expanding the Functional Scope of the Fmoc-Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Reductionist Approach in Peptide-Based Nanotechnology.Annual review of biochemistry · 2018Review
- Multicomponent peptide assemblies.Chemical Society reviews · 2018Review
- An inflammatory memory and angiogenic self-assembling nanofiber hydrogel scaffold seeded withRSC advances · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of building blocks into supramolecular polymers allows the fabrication of diverse functional architectures at the nanoscale. The use of minimal assembly units to explore polymer dynamics and phase transitions significantly contributes to the application of polymer physicochemical paradigms in the field of supramolecular polymers. We present a minimal model that displays spontaneous coordinated structural transitions between micro- and nanostructures, hydrogels with nanoscale order, and single crystals. The simple amphiphilic 9-fluorenylmethoxycarbonyl-3,4-dihydroxyphenylalanine (Fmoc-DOPA) modified amino acid undergoes a noninduced transition from spherical assemblies into nanofibrils followed by sol-gel transition, nanotube formation via intermediate assembly, and crystallization within the gel. Notably, the transition kinetics is slow enough to allow both multistage and multiscale characterization of the supramolecular arrangement using electron microscopy, vibrational and circular dichroism spectroscopies, nuclear magnetic resonance, and x-ray crystallography. This minimalistic system is the first comprehensive model for a complete spontaneous structural transition between diverse states governed by distinct molecular interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.