Evidence map›Paper›PMID 26933665›Full record

ArticleOpen forum infectious diseases2016

Characteristics and Treatment Outcomes of Propionibacterium acnes Prosthetic Shoulder Infections in Adults.

Damani A Piggott, Yvonne M Higgins, Michael T Melia, Brandon Ellis, Karen C Carroll, Edward G McFarland, Paul G Auwaerter

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Rifampin-accompanied antibiotic regimens in the treatment of prosthetic joint infections: a frequentist and Bayesian meta-analysis of current evidence.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Pooled it
  3. Review
  4. Review
  5. Successful Treatment ofOpen forum infectious diseases · 2023
    Article
  6. Review
  7. Antibiotics (Basel, Switzerland) · 2022
    Article
  8. Occult prosthetic aortic valve endocarditis caused byAnnals of the Royal College of Surgeons of England · 2022
    Article
  9. Clindamycin Efficacy forAntibiotics (Basel, Switzerland) · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Prosthetic Shoulder Joint Infection byAntibiotics (Basel, Switzerland) · 2021
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Damani A PiggottDivision of Infectious Diseases; Department of Epidemiology, Johns Hopkins University School of Public Health.
Yvonne M HigginsDivision of Infectious Diseases.
Michael T MeliaDivision of Infectious Diseases.
Brandon EllisJohns Hopkins Hospital Microbiology Laboratory.
Karen C CarrollDivision of Infectious Diseases; Division of Medical Microbiology, Department of Pathology.
Edward G McFarlandDivision of Shoulder Surgery, Department of Orthopedic Surgery , Johns Hopkins University School of Medicine.
Paul G AuwaerterDivision of Infectious Diseases; Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases, Baltimore, Maryland.
Office of Infectious Diseases · USJohns Hopkins Hospital · USJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background.  Prosthetic joint infections (PJIs) significantly complicate joint arthroplasties. Propionibacterium acnes is an increasingly recognized PJI pathogen, yet limited clinical and therapeutic data exist. We sought to examine characteristics of P. acnes shoulder PJIs and compare surgical and nonsurgical management outcomes. Methods.  A retrospective analysis of P. acnes shoulder PJIs was conducted at an academic center in Baltimore, Maryland from 2000 to 2013. Results.  Of 24 cases of P. acnes shoulder PJIs, 92% were diagnosed after extended culture implementation; 42% in the delayed and 46% in the late postsurgical period. Joint pain and diminished function were the predominant presenting clinical signs. Erythrocyte sedimentation rate and C-reactive protein elevations occurred in 47% and 44%, respectively. All tested isolates were susceptible to β-lactams, moxifloxacin, vancomycin, and rifampin. Clindamycin resistance was identified in 6%. Of the antibiotic-only treated cases, 67% had a favorable clinical outcome compared with 71% (P = 1.0) of cases with a combined antibiotic-surgical approach. Favorable outcome with and without rifampin therapy was 73% and 60% (P = .61), respectively. Conclusions.  Propionibacterium acnes PJI diagnoses increased with extended culture. Inflammatory markers were elevated in a minority of cases. Isolates maintained broad antimicrobial susceptibility. Compared to combined antibiotic-surgical approaches, antibiotic-only approaches were similarly successful in selected cases.

Indexed as

antimicrobial susceptibilityPropionibacterium acnesprosthetic joint infectionshoulder prosthesis

Identifiers

PMID26933665
PMCPMC4772881
OpenAlexW2271867110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.