ArticleTranslational vision science & technology2016
Effects of Intraframe Distortion on Measures of Cone Mosaic Geometry from Adaptive Optics Scanning Light Ophthalmoscopy.
Article in Translational vision science & technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Two-lens telecentric model eyes for image distortion measurement in adaptive optics ophthalmoscopes.Biomedical optics express · 2026Article
- Telecentric model eye for correction of image distortion in adaptive optics ophthalmoscopes.Biomedical optics express · 2025Article
- Adaptive Optics Imaging of Inherited Retinal Disease.Cold Spring Harbor perspectives in medicine · 2023Review
- Comprehensive automatic processing and analysis of adaptive optics flood illumination retinal images on healthy subjects.Biomedical optics express · 2023Article
- Automated image processing pipeline for adaptive optics scanning light ophthalmoscopy.Biomedical optics express · 2021Article
- Emulated retinal image capture (ERICA) to test, train and validate processing of retinal images.Scientific reports · 2021Article
- Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure.Translational vision science & technology · 2021Article
- Template free eye motion correction for scanning systems.Optics letters · 2021Article
- Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2.Journal of clinical medicine · 2020Article
- A 2-Year Longitudinal Study of Normal Cone Photoreceptor Density.Investigative ophthalmology & visual science · 2019Article
- Adaptive optics imaging of inherited retinal diseases.The British journal of ophthalmology · 2018Review
- High speed adaptive optics ophthalmoscopy with an anamorphic point spread function.Optics express · 2018Article
- Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina.Advances in experimental medicine and biology · 2018Article
- Agreement in Cone Density Derived from Gaze-Directed Single Images Versus Wide-Field Montage Using Adaptive Optics Flood Illumination Ophthalmoscopy.Translational vision science & technology · 2017Article
- Automated Photoreceptor Cell Identification on Nonconfocal Adaptive Optics Images Using Multiscale Circular Voting.Investigative ophthalmology & visual science · 2017Article
- Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy.Investigative ophthalmology & visual science · 2017Article
- Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging.Investigative ophthalmology & visual science · 2017Review
- An Automated Reference Frame Selection (ARFS) Algorithm for Cone Imaging with Adaptive Optics Scanning Light Ophthalmoscopy.Translational vision science & technology · 2017Article
- Article
- De-warping of images and improved eye tracking for the scanning laser ophthalmoscope.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeTo characterize the effects of intraframe distortion due to involuntary eye motion on measures of cone mosaic geometry derived from adaptive optics scanning light ophthalmoscope (AOSLO) images.
methodsWe acquired AOSLO image sequences from 20 subjects at 1.0, 2.0, and 5.0° temporal from fixation. An expert grader manually selected 10 minimally distorted reference frames from each 150-frame sequence for subsequent registration. Cone mosaic geometry was measured in all registered images (
resultsWe observed substantial variation across subjects in the repeatability of density (1.2%-8.7%), inter-cell distance (0.8%-4.6%), percentage of six-sided Voronoi cells (0.8%-10.6%), and Voronoi cell area regularity (VCAR) (1.2%-13.2%). The average of all metrics extracted from AOSLO images (with the exception of VCAR) was not significantly different than those derived from AO-fundus images, though there was variability between individual images.
conclusionsOur data demonstrate that the intraframe distortion found in AOSLO images can affect the accuracy and repeatability of cone mosaic metrics. It may be possible to use multiple images from the same retinal area to approximate a "distortionless" image, though more work is needed to evaluate the feasibility of this approach. TRANSLATIONAL RELEVANCE: Even in subjects with good fixation, images from AOSLOs contain intraframe distortions due to eye motion during scanning. The existence of these artifacts emphasizes the need for caution when interpreting results derived from scanning instruments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.