Evidence map›Paper›PMID 26933488›Full record

ReviewExperimental & translational stroke medicine2016

Cerebral collateral circulation in experimental ischemic stroke.

Elisa Cuccione, Giada Padovano, Alessandro Versace, Carlo Ferrarese, Simone Beretta

Open access · hybridAbstract readReview
In one paragraph

Review in Experimental & translational stroke medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  6. Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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  7. Review
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  18. Frontiers in cell and developmental biology · 2020
    Article
  19. Article
  20. Anti-apoptotic activity of ETScientific reports · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elisa CuccioneLaboratory of Experimental Stroke Research, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy ; PhD Programme in Neuroscience, University of Milano Bicocca, Monza, Italy.
Giada PadovanoLaboratory of Experimental Stroke Research, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy.
Alessandro VersaceLaboratory of Experimental Stroke Research, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy.
Carlo FerrareseLaboratory of Experimental Stroke Research, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy ; Milan Center for Neuroscience (NeuroMi), Milan, Italy.
Simone BerettaLaboratory of Experimental Stroke Research, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy ; Milan Center for Neuroscience (NeuroMi), Milan, Italy.
University of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral collateral circulation is a subsidiary vascular network, which is dynamically recruited after arterial occlusion, and represents a powerful determinant of ischemic stroke outcome. Although several methods may be used for assessing cerebral collaterals in the acute phase of ischemic stroke in humans and rodents, they are generally underutilized. Experimental stroke models may play a unique role in understanding the adaptive response of cerebral collaterals during ischemia and their potential for therapeutic modulation. The systematic assessment of collateral perfusion in experimental stroke models may be used as a "stratification factor" in multiple regression analysis of neuroprotection studies, in order to control the within-group variability. Exploring the modulatory mechanisms of cerebral collaterals in stroke models may promote the translational development of therapeutic strategies for increasing collateral flow and directly compare them in term of efficacy, safety and feasibility. Collateral therapeutics may have a role in the hyperacute (even pre-hospital) phase of ischemic stroke, prior to recanalization therapies.

Indexed as

Cerebral collateralsCollateral therapeuticsExperimental stroke modelsInfarct size variabilityIschemic penumbraIschemic stroke

Identifiers

PMID26933488
PMCPMC4772465
OpenAlexW2289875158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.