ArticleOxidative medicine and cellular longevity2016
Hippophae rhamnoides L. Fruits Reduce the Oxidative Stress in Human Blood Platelets and Plasma.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 62 citations in OpenAlex.
- Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Clinical interventions in aging · 2019Trial
- Sea buckthorn berry extract favorably affects bone metabolism-related biomarkers and collagen deposition in cultured rat primary osteoblasts.Open life sciences · 2026Article
- Ethnopharmacology, phytochemistry, and pharmacology of sea buckthorn (Frontiers in pharmacology · 2026Review
- Beneficial effects ofPharmaceutical biology · 2025Review
- The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats.Journal of applied oral science : revista FOB · 2025Article
- Oxidative Stress Induced by Cortisol in Human Platelets.International journal of molecular sciences · 2024Article
- Effects ofFrontiers in molecular biosciences · 2024Review
- Research progress of sea buckthorn (Frontiers in cardiovascular medicine · 2024Review
- Effect of Polyphenols in Sea Buckthorn Berry on Chemical Mediator Release from Mast Cells.Preventive nutrition and food science · 2023Article
- A Novel Symbiotic Beverage Based on Sea Buckthorn, Soy Milk and Inulin: Production, Characterization, Probiotic Viability, and Sensory Acceptance.Microorganisms · 2023Article
- Inside the Mechanism of Action of Three Pyrazole Derivatives in Human Platelets and Endothelial Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Anti-Obesity Effects of Isorhamnetin and Isorhamnetin Conjugates.International journal of molecular sciences · 2022Review
- Article
- Preparations from Various Organs of Sea Buckthorn (Nutrients · 2022Review
- Phytochemistry, health benefits, and food applications of sea buckthorn (Frontiers in nutrition · 2022Review
- The Fading Wild Plant Food-Medicines in Upper Chitral, NW Pakistan.Foods (Basel, Switzerland) · 2021Article
- Sea Buckthorn in Plant Based Diets. An Analytical Approach of Sea Buckthorn Fruits Composition: Nutritional Value, Applications, and Health Benefits.International journal of environmental research and public health · 2021Review
- Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds.Scientific reports · 2021Article
- Unsaturated fatty acid-enriched extract from Hippophae rhamnoides seed reduces skin dryness through up-regulating aquaporins 3 and hyaluronan synthetases 2 expressions.Journal of cosmetic dermatology · 2021Article
- The bioactive components as well as the nutritional and health effects of sea buckthorn.RSC advances · 2020Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of the phenolic fraction from Hippophae rhamnoides fruits on the production of thiobarbituric acid reactive substances (TBARS, a marker of lipid peroxidation) and the generation of superoxide anion (O2 (-∙)) in human blood platelets (resting platelets and platelets stimulated by a strong physiological agonist, thrombin) were studied in vitro. We also examined antioxidant properties of this fraction against human plasma lipid peroxidation and protein carbonylation induced by a strong biological oxidant, hydrogen peroxide (H2O2) or H2O2/Fe (a donor of hydroxyl radicals). The tested fraction of H. rhamnoides (0.5- 50 µg/mL; the incubation time: 15 and 60 min) inhibited lipid peroxidation induced by H2O2 or H2O2/Fe. The H. rhamnoides phenolic fraction inhibited not only plasma lipid peroxidation, but also plasma protein carbonylation stimulated by H2O2 or H2O2/Fe. Moreover, the level of O2 (-∙) in platelets significantly decreased. In comparative experiments, the H. rhamnoides fraction was a more effective antioxidant than aronia extract or grape seed extract (at the highest tested concentration, 50 µg/mL). The obtained results suggest that H. rhamnoides fruits may be a new, promising source of natural compounds with antioxidant and antiplatelet activity beneficial not only for healthy people, but also for those with oxidative stress-associated diseases.
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