Observational studyLung2016
Factors Associated with Depression in COPD: A Multicenter Study.
Observational study in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between mental health and chronic obstructive pulmonary disease (COPD) outcomes: systematic review and meta-analysis.BMJ open respiratory research · 2026Pooled it
- The Psychological and Physical Benefits of Progressive Muscle Relaxation in Chronic Respiratory Diseases: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Association between impairment of lung function and risk of anxiety and depression in patients with chronic obstructive pulmonary disease-a systematic review.Systematic reviews · 2024Pooled it
- Efficacy and Safety of Escitalopram in Alleviating Depression and Anxiety Symptoms in COPD Patients: A Randomized Double-Blind Placebo-Controlled Trial.International journal of chronic obstructive pulmonary disease · 2026Trial
- Mood Monitoring Over One Year for People With Chronic Obstructive Pulmonary Disease Using a Mobile Health System: Retrospective Analysis of a Randomized Controlled Trial.JMIR mHealth and uHealth · 2019Trial
- Group singing improves depression and life quality in patients with stable COPD: a randomized community-based trial in China.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Trial
- COPD and Comorbid Mental Health: Addressing Anxiety, and Depression, and Their Clinical Management.Medicina (Kaunas, Lithuania) · 2025Review
- Influencing factors of good quality of life among chronic obstructive pulmonary disease patients living in Zhejiang Province, China.Scientific reports · 2024Article
- Impact of Frailty on Symptom Burden in Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2024Review
- Efficacy and cerebral mechanisms of acupuncture for chronic obstructive pulmonary disease: study protocol for a multicenter, randomized controlled neuroimaging trial.Frontiers in neurology · 2024Article
- Psychophysical and Social Functioning of Patients with Chronic Obstructive Lung Disease and Depression.European journal of investigation in health, psychology and education · 2023Article
- Incidence of treatment-resistant depression during the first mood depressive episode.La Tunisie medicale · 2023Article
- Frequency and Associated Factors of Suicidal Ideation in Patients with Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2022Article
- Impact of anxiety and depression on the prognosis of copd exacerbations.BMC pulmonary medicine · 2022Observational
- Assessing Symptom Burden and Depression in Subjects With Chronic Respiratory Insufficiency.Journal of palliative care · 2022Article
- Article
- Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease.Biomedicines · 2021Article
- Dyspnea on Exercise Is Associated with Overall Symptom Burden in Patients with Chronic Respiratory Insufficiency.Palliative medicine reports · 2021Article
- Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Intercellular Communication by Vascular Endothelial Cell-Derived Extracellular Vesicles and Their MicroRNAs in Respiratory Diseases.Frontiers in molecular biosciences · 2020Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDepression is a prevalent comorbidity in COPD and has an impact on the prognosis of these patients, thereby making it important to study the factors associated with depression in patients with COPD.
methodA multicenter, observational and cross-sectional study was conducted to study the factors associated with depression in patients with COPD measured by the hospital anxiety and depression (HAD) questionnaire. We analyzed anthropometric variables and the number of exacerbations in the previous year and calculated the 6-min walking test and the body mass index, airflow obstruction, dyspnea, and exercise (BODE) index. All the patients completed the quality of life EQ-5D and the LCADL physical activity questionnaires. The relationship of these variables with depression was evaluated with two multiple logistic regression models.
resultsOne hundred fifteen patients were evaluated (93 % male) with a mean age of 66.9 years (SD 8.8) and a mean FEV1 % of 44.4 % (SD 15.7 %). 24.3 % presented symptoms of depression (HAD-D > 8). These latter patients had worse lung function, greater dyspnea, reduced exercise capacity, a higher score in the BODE index, poorer quality of life, reduced physical activity, and more exacerbations. In the first logistic regression model, quality of life and the BODE index were associated with depression (AUC: 0.84; 0.74-0.94). In the second model including the variables in the BODE index, quality of life and dyspnea measured with the MRC scale (AUC: 0.87; 0.79-0.95) were associated with depression.
conclusionsNearly one-quarter of the patients with COPD in this study presented clinically significant depression associated with worse quality of life, reduced exercise capacity, greater dyspnea, and a higher score in the BODE index.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.