Evidence map›Paper›PMID 26932598›Full record

ArticleScientific reports2016

Polymorphisms in the 5' upstream regulatory region of p21(WAF1/CIP1) and susceptibility to oesophageal squamous cell carcinoma.

Wenjun Yang, Yong Li, Tao Ning, Hong Cai, Zhiqiang Chen, Ying Dong, Yang Ke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wenjun YangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Genetics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, P. R. China.
Yong LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Genetics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, P. R. China.
Tao NingKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Genetics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, P. R. China.
Hong CaiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Genetics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, P. R. China.
Zhiqiang ChenRadiology Department of General Hospital, Ningxia Medical University, Yinchuan, Ningxia, 750004, P. R. China.
Ying DongKey Laboratory of Fertility Preservation and Maintenance (Ministry of Education), Cancer Institute of the General Hospital, Ningxia Medical University, Yinchuan, Ningxia, 750004, P. R. China.
Yang KeKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Genetics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, P. R. China.
Peking University · CNNingxia Medical University · CNNingxia Medical University General Hospital · CNPeking University Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to scan the 5'-upstream regulatory region of the p21 gene to identify all putative functional single nucleotide polymorphisms (SNPs) and to evaluate the contribution of p21 variants to oesophageal squamous cell carcinoma (ESCC) in the Chinese Han population. Common SNPs were identified, and both locus-based and haplotype-based association tests were used to evaluate the potential risk of these p21 gene polymorphisms for ESCC. Immunohistochemistry assay was further performed to detect the P21 protein expression in ESCC specimens. Twenty three SNPs were identified and seven Tagging SNPs were chosen to represent all 23 SNPs. Univariate analysis indicated that the rs3829963 C and the rs2395655 G alleles increased susceptibility to ESCC (OR = 1.606 and OR = 1.572, respectively). The rs3829963 C and rs2395655 G alleles, combined with cigarette smoking, could further increase the risk for ESCC (OR = 2.657 and OR = 2.828, respectively). Additionally, the rs2395655 G allele appeared to elevate the positive rate of P21 expression in ESCC tissues, as compared to the A allele. This report demonstrates for the first time that rs3829963 and rs2395655, in the promoter of the p21 gene are potentially functional, modulating susceptibility to ESCC among the high-risk cigarette-smoking Chinese population.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgedAsian PeopleCarcinoma, Squamous CellCase-Control StudiesCyclin-Dependent Kinase Inhibitor p21Esophageal NeoplasmsFemaleGenotypeHaplotypesHumansLinkage DisequilibriumMaleMiddle AgedCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21

Identifiers

PMID26932598
PMCPMC4773838
OpenAlexW2291892270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.