ArticleSurgical endoscopy2016
Peroral endoscopic myotomy for esophageal achalasia: outcomes of the first over 100 patients with short-term follow-up.
Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The 2 years' long-term efficacy and safety of peroral endoscopic myotomy for the treatment of achalasia: a systematic review.Journal of cardiothoracic surgery · 2019Pooled it
- Bladder pressure monitoring and COJournal of clinical monitoring and computing · 2018Trial
- Third space endoscopy pulmonary complications and chylothorax post peroral endoscopic myotomy.World journal of methodology · 2025Review
- Peroral endoscopic myotomy in children with achalasia: A review of the literature.World journal of gastrointestinal endoscopy · 2025Review
- Efficacy of peroral endoscopic myotomy for improving sleep problems in patients with achalasia.DEN open · 2025Article
- Pull-back myotomy to prevent mucosal injury during peroral endoscopic myotomy for jackhammer esophagus.Endoscopy · 2024Article
- Routine esophagram to detect early esophageal leakage after peroral endoscopic myotomy.Endoscopy international open · 2024Article
- Review
- Peroral endoscopic myotomy: is it better to perform it in naive patients or as second-line therapy? Results of an open-label-controlled study in 105 patients.Surgical endoscopy · 2023Article
- Updates in the Field of Submucosal Endoscopy.Life (Basel, Switzerland) · 2022Review
- Safety and effectiveness of sling fiber preservation POEM to reduce severe post-procedural erosive esophagitis.Surgical endoscopy · 2022Article
- Efficacy and safety of peroral endoscopic myotomy in 100 older patients.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Per-oral endoscopic dual myotomy for the treatment of achalasia.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- The Canadian POEM Experience: The First 50 Patients.Journal of the Canadian Association of Gastroenterology · 2021Article
- A Narrative Review of update in per oral endoscopic myotomy (POEM) and endoscopic esophageal surgery.Annals of translational medicine · 2021Review
- Peroral Endoscopic Myotomy for Esophageal Achalasia in Portugal: Outcomes of the First Prospective Series.GE Portuguese journal of gastroenterology · 2021Article
- Role of Rapid Drink Challenge During Esophageal High-resolution Manometry in Predicting Outcome of Peroral Endoscopic Myotomy in Patients With Achalasia.Journal of neurogastroenterology and motility · 2020Article
- Multicenter collaborative retrospective evaluation of peroral endoscopic myotomy for esophageal achalasia: analysis of data from more than 1300 patients at eight facilities in Japan.Surgical endoscopy · 2020Article
- Peroral endoscopic myotomy leads to higher rates of abnormal esophageal acid exposure than laparoscopic Heller myotomy in achalasia.Surgical endoscopy · 2019Article
- Long-Term Efficacy of Peroral Endoscopic Myotomy for Patients with Achalasia: Outcomes with a Median Follow-Up of 36 Months.Digestive diseases and sciences · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPOEM is a recently developed achalasia treatment method, which combines the efficacy of surgical myotomy with the benefits of endoscopic procedures. Very few studies have focussed on the efficacy and usefulness of POEM in over 100 cases.
methodsThe first 100 adult patients treated according to standard POEM technique in a single center and followed up for 3 months were identified and included in this study (men 42; women 58; mean age 48.2 ± 18.8; range 9-91 years) The pre- and postoperative assessments included Eckardt scores, manometry, endoscopy, and monitoring pH.
resultsMean operative time was 150.8 ± 49.3 min (75-370 min). Adverse events over Grade IIIb by the Clavien-Dindo classification were not encountered. The mean preoperative and postoperative lower esophageal sphincter pressures were 43.6 ± 26.2 and 20.9 ± 12.7 mmHg, respectively, indicating a statistically significant decrease after POEM (P < 0.05). The mean preoperative and postoperative integrated relaxation pressure values were 33.5 ± 15.2 and 15.3 ± 6.5 mmHg (P < 0.05). Furthermore, the Eckardt score significantly decreased from 5.9 ± 2.5 preoperatively to 0.8 ± 0.9 postoperatively (P < 0.05). Clinical success was documented in 99 % of the patients. Short-term outcomes after POEM were extremely good and independent of the age, type of achalasia, and previous treatment method. The percent of monitoring time with a pH < 4 was 25.6 % (22/86) in patients not on proton-pump inhibitors. Nine patients were diagnosed with symptomatic gastroesophageal reflux disease (GERD); patients with reflux esophagitis and symptomatic GERD improved with PPI treatment.
conclusionsOur results confirm the efficacy of POEM in a large patient series and support POEM as one of the first-line achalasia therapies in the near future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.