Evidence map›Paper›PMID 26932543›Full record

ArticleScientific reports2016

Quantifying Demyelination in NK venom treated nerve using its electric circuit model.

H K Das, D Das, R Doley, P P Sahu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

H K DasDepartment of Electronics and Communication Engg., Tezpur University, Tezpur-784028, Assam, India.
D DasDepartment of Molecular Biology and Biotechnology, Tezpur University, Tezpur-784028, Assam, India.
R DoleyDepartment of Molecular Biology and Biotechnology, Tezpur University, Tezpur-784028, Assam, India.
P P SahuDepartment of Electronics and Communication Engg., Tezpur University, Tezpur-784028, Assam, India.
Tezpur University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reduction of myelin in peripheral nerve causes critical demyelinating diseases such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, etc. Clinical monitoring of these diseases requires rapid and non-invasive quantification of demyelination. Here we have developed formulation of nerve conduction velocity (NCV) in terms of demyelination considering electric circuit model of a nerve having bundle of axons for its quantification from NCV measurements. This approach has been validated and demonstrated with toad nerve model treated with crude Naja kaouthia (NK) venom and also shows the effect of Phospholipase A2 and three finger neurotoxin from NK-venom on peripheral nerve. This opens future scope for non-invasive clinical measurement of demyelination.

Indexed as

ElectricityModels, NeurologicalAnimalsAnuraAxonsCell MembraneDemyelinating DiseasesElapid VenomsIon ChannelsNeural ConductionPhospholipases A2Sciatic NerveElapid VenomsIon ChannelsNaja kaouthia venomPhospholipases A2

Identifiers

PMID26932543
PMCPMC4773768
OpenAlexW2288566731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.