ArticleAlimentary pharmacology & therapeutics2016
Helicobacter pylori in children with asthmatic conditions at school age, and their mothers.
Article in Alimentary pharmacology & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The association between Helicobacter pylori infection and asthma risk: an updated systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Effect of polyphenol compounds onBMJ open · 2023Pooled it
- The effects of Helicobacter pylori eradication and development of immune-mediated disorder in children: a nationwide population-based study in Korea.The Korean journal of internal medicine · 2026Article
- Association ofPediatric gastroenterology, hepatology & nutrition · 2025Article
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Inverse association betweenGerms · 2019Article
- The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood.Current allergy and asthma reports · 2019Review
- Helicobacter pylori Infection: New Facts in Clinical Management.Current treatment options in gastroenterology · 2018Review
- Review
- Asthma and the microbiome:Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017Review
- Review
- Is Helicobacter pylori Anyway Pathogen in Children?Inquiry : a journal of medical care organization, provision and financingArticle
- Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHelicobacter pylori prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena.
aimsTo examine the association between H. pylori colonisation in children and risk of asthma and related conditions at school age. We secondly examined additional effects of maternal H. pylori status by pairing with children's status.
methodsThis study was embedded in a multi-ethnic population-based cohort in Rotterdam, The Netherlands. We measured anti-H. pylori and anti-CagA antibodies in serum of children obtained at age 6 years, and of their mothers obtained during midpregnancy. Asthma or related conditions were reported for children at age 6 years. We used multivariate logistic regression analyses among 3797 subjects.
resultsIn children, the H. pylori positivity rate was 8.7%, and 29.2% of these were CagA-positive. A child's colonisation with a CagA-negative-H. pylori strain was associated with an increased risk of asthma (Odds ratio 2.11; 95% CI 1.23-3.60), but this differed for European (3.64; 1.97-6.73) and non-European (0.52; 0.14-1.89) children. When taking into account maternal H. pylori status, only H. pylori-positive children with an H. pylori-negative mother had increased risk of asthma (2.42; 1.11-5.27), accounting for 3.4% of the asthma risk.
conclusionsColonisation of a European child with a CagA-negative-H. pylori strain at age 6 was associated with an increased prevalence of asthma, but there was no association for non-European children. The underlying mechanisms for the observed risk differences require further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.