Evidence map›Paper›PMID 26932352›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016

Protecting the Kidney in Liver Transplant Recipients: Practice-Based Recommendations From the American Society of Transplantation Liver and Intestine Community of Practice.

J Levitsky, J G O'Leary, S Asrani, P Sharma, J Fung, A Wiseman, C U Niemann

2 registry-linked trialsAbstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05275907 phase4withdrawnnot on this mapstarted 2022, after this paper: background citation

Pilot Study to Assess Blockade of Calcium Channels and Sodium Chloride Cotransporters for Physiologic Abnormalities in Liver Transplant Associated Hypertension

TypeinterventionalSponsorNorthwestern UniversityRan2022 to 2023Enrolled0ConditionsHigh Blood Pressure, Liver Transplant, Renal Function AbnormalArmsAmlodipine Besylate, Chlorthalidone
NCT05335551 unknown statusnot on this mapstarted 2022, after this paper: background citation

A Clinical Pilot Study to Test the Acceptability and Feasibility of TruGraf Liver and TRAC Liver Testing as Part of Standard of Care: Optimizing Liver ImmunoSuppression (TRU-IMMUNO)

TypeobservationalSponsorTransplant Genomics, Inc.Ran2022 to 2023Enrolled130ConditionsLiver Transplant RejectionArmsPatients monitored with TruGraf and TRAC Liver testing
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  4. Review
  5. Article
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  7. Article
  8. Review
  9. Review
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  11. Review
  12. European Society for Organ Transplantation Consensus Statement on Biomarkers in Liver Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Identification of peripheral CD154Clinical and experimental immunology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J LevitskyDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
J G O'LearyDivision of Hepatology, Baylor University Medical Center, Dallas, TX.
S AsraniDivision of Hepatology, Baylor University Medical Center, Dallas, TX.
P SharmaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI.ORCID 0000-0002-1182-0579
J FungDepartment of Surgery, Transplantation Center, The Cleveland Clinic, Cleveland, OH.
A WisemanDivision of Renal Diseases and Hypertension, Department of Medicine, University of Colorado School of Medicine, Denver, CO.
C U NiemannDepartment of Anesthesia and Surgery, University of California at San Francisco, San Francisco, CA.

Funding

Proteogenomics for Organ Transplantation: Prediction, Diagnosis, InterventionU01AI084146 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABECASSIS, MICHAEL M · 2009 to 2013
$10.5M
Predicting the burden of renal disease among liver transplant recipientsK08DK088946 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHARMA, PRATIMA · 2011 to 2015
$765k
Proteomic Predictors of Chronic Kidney Disease in Liver Transplant RecipientsR21AI113916 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEVITSKY, JOSH · 2014 to 2015
$428k
Burden of Hospitalization After Liver TransplantationR03DK102480 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHARMA, PRATIMA · 2015 to 2016
$162k
NIAID NIH HHS R21 AI113916NIAID NIH HHS U01 AI084146NIDDK NIH HHS K08 DK088946NIDDK NIH HHS R03 DK102480
6 · The paper itself

Abstract

Both acute and chronic kidney disease are common after liver transplantation and result in significant morbidity and mortality. The introduction of the Model for End-stage Liver Disease score has directly correlated with an increased prevalence of perioperative renal dysfunction and the number of simultaneous liver-kidney transplantations performed. Kidney dysfunction in this population is typically multifactorial and related to preexisting conditions, pretransplantation renal injury, perioperative events, and posttransplantation nephrotoxic immunosuppressive therapies. The management of kidney disease after liver transplantation is challenging, as by the time the serum creatinine level is significantly elevated, few interventions affect the course of progression. Also, immunological factors such as antibody-mediated kidney rejection have become of greater interest given the rising liver-kidney transplant population. Therefore, this review, assembled by experts in the field and endorsed by the American Society of Transplantation Liver and Intestine Community of Practice, provides a critical assessment of measures of renal function and interventions aimed at preserving renal function early and late after liver and simultaneous liver-kidney transplantation. Key points and practice-based recommendations for the prevention and management of kidney injury in this population are provided to offer guidance for clinicians and identify gaps in knowledge for future investigations.

Indexed as

HumansIntestinesKidney Failure, ChronicLiver TransplantationPractice Guidelines as TopicSocieties, Medicalclinical research/practicecomplication: medical/metabolicglomerular filtration rate (GFR)immunosuppression/immune modulationimmunosuppressive regimenskidney (native) function/dysfunctionkidney transplantation/nephrologyliver allograft function/dysfunctionliver transplantation/hepatologymaintenancetranslational research/science

Identifiers

PMID26932352
PMCPMC5007154

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.