SynthesisIntensive care medicine2016
Systematic review of cardiac output measurements by echocardiography vs. thermodilution: the techniques are not interchangeable.
Synthesis in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- A recommendation for the use of electrical biosensing technology in neonatology.Pediatric research · 2025Guideline
- Accuracy and Trending Ability of Electrical Biosensing Technology for Non-invasive Cardiac Output Monitoring in Neonates: A Systematic Qualitative Review.Frontiers in pediatrics · 2022Pooled it
- Cardiac output measurements via echocardiography versus thermodilution: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Agreement between manual and automatic ultrasound measurement of the velocity-time integral in the left ventricular outflow tract in intensive care patients: evaluation of the AUTO-VTI® tool.Journal of clinical monitoring and computing · 2025Trial
- The impact of N-acetylcysteine and ascorbic acid in contrast-induced nephropathy in critical care patients: an open-label randomized controlled study.Critical care (London, England) · 2017Trial
- The Role of PoCUS in the Diagnosis and Early Monitoring of Cardiogenic Shock in the Emergency Department: A Narrative Review.Reviews in cardiovascular medicine · 2026Review
- Haemodynamic alterations associated with hepatic vascular malformations in hereditary haemorrhagic telangiectasia: A cohort study.JHEP reports : innovation in hepatology · 2026Article
- Septic Cardiomyopathy: Age-Dependent Physiology and Hemodynamic Aspects-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Fluid challenge and left ventricular myocardial performance index assessed by transthoracic echocardiography with tissue Doppler imaging in critically ill patients with regular rhythm.Frontiers in medicine · 2026Article
- Prevalence of iron deficiency and its association with cardiac function in dogs with various stages of myxomatous mitral valvular disease.Frontiers in veterinary science · 2026Article
- Early assessment of fluid tolerance (VExUS) and stroke volume (LVOT-VTI) to predict adverse outcomes in emergency department patients with suspected sepsis.Annals of intensive care · 2026Article
- Correlation between carotid Doppler ultrasound-derived parameters and cardiac output measurements: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement.Anesthesiology · 2025Review
- Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population.Scientific reports · 2025Article
- Fluid management strategies in critically ill patients with ARDS: a narrative review.European journal of medical research · 2025Review
- Extracorporeal Blood Flow Rate: Target the Right Thing!American journal of respiratory and critical care medicine · 2024Article
- Observational
- Characteristics of pulmonary artery catheter use in multicenter ICUs in Japan and the association with mortality: a multicenter cohort study using the Japanese Intensive care PAtient Database.Critical care (London, England) · 2023Observational
- Use of thoracic ultrasound in acute respiratory distress syndrome.Annals of translational medicine · 2023Review
- Utilizing Spontaneous Ventilation Modes in Patients Underwent Corrective Surgery for Right Ventricular Outflow Tract Obstructive Congenital Heart Disease: A Crossover Study.Reviews in cardiovascular medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEchocardiography is frequently used in the hemodynamic evaluation of critically ill patients, but inaccurate measurements may lead to wrong clinical decisions. The aim of our systematic review was to investigate the interchangeability of echocardiography with thermodilution technique in measuring cardiac output and its changes.
methodsIn August 2015 we systematically searched electronic databases and included studies investigating the echocardiographic measurement of cardiac output compared with thermodilution technique using the Bland-Altman method. Two authors independently reviewed the studies and extracted data on type of measurements, clinical setting and characteristics, and those of the Bland-Altman and trending ability analyses.
resultsWe identified 13,834 citations and included 24 studies in the final analysis. The median number of participants was 32 (range 8-65). Most of the studies assessed left-sided heart structures and the majority had small bias, wide limits of agreement, and high percentage error between echocardiography and thermodilution. In only two of the 24 studies the precision of each technique (echocardiography and thermodilution) was assessed before comparing them. In the single study evaluating trending ability using valid methodology, agreement was observed between echocardiography and thermodilution in detecting the directional changes in cardiac output, but the magnitude of changes varied considerably.
conclusionsThe majority of studies comparing echocardiography with thermodilution were difficult to interpret, but current evidence does not support interchangeability between these techniques in measuring cardiac output. The techniques may be interchangeable in tracking directional changes in cardiac output, but this has to be confirmed in large high-quality studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.