ArticleScientific reports2016
Influence of plasma-activated compounds on melanogenesis and tyrosinase activity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Synthesis, QSAR analysis and molecular docking study of a new series of 3-hydroxypyridine-4-one derivatives as anti-tyrosinase agents.BMC chemistry · 2026Article
- Cold atmospheric plasma (CAP): a revolutionary approach in dermatology and skincare.European journal of medical research · 2024Review
- A novel liquid plasma derivative inhibits melanogenesis through upregulation of Nrf2.Scientific reports · 2024Article
- Exploring the Influence of Cold Plasma on Epidermal Melanogenesis In Situ and In Vitro.International journal of molecular sciences · 2024Article
- Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid-Eugenol Esters.Molecules (Basel, Switzerland) · 2023Article
- Article
- Changes in Biochemical Properties and Activity of Trypsin-like Protease (Foods (Basel, Switzerland) · 2022Article
- Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes.Biochemistry and biophysics reports · 2021Article
- Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: a systematic review.RSC advances · 2021Review
- Ishophloroglucin A Isolated fromMarine drugs · 2020Article
- Effect of Ling-Gui-Zhu-Gan decoction major components on the plasma protein binding of metoprolol using UPLC analysis coupled with ultrafiltration.RSC advances · 2018Article
- Tyrosinase-based TLC Autography for anti-melanogenic drug screening.Scientific reports · 2018Article
- Interaction studies of carbon nanomaterials and plasma activated carbon nanomaterials solution with telomere binding protein.Scientific reports · 2017Article
- The Role of Free Radicals in Hemolytic Toxicity Induced by Atmospheric-Pressure Plasma Jet.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many organic chemists around the world synthesize medicinal compounds or extract multiple compounds from plants in order to increase the activity and quality of medicines. In this work, we synthesized new eugenol derivatives (ED) and then treated them with an N2 feeding gas atmospheric pressure plasma jet (APPJ) to increase their utility. We studied the tyrosinase-inhibition activity (activity test) and structural changes (circular dichroism) of tyrosinase with ED and plasma activated eugenol derivatives (PAED) in a cell-free environment. Later, we used docking studies to determine the possible interaction sites of ED and PAED compounds with tyrosinase enzyme. Moreover, we studied the possible effect of ED and PAED on melanin synthesis and its mechanism in melanoma (B16F10) cells. Additionally, we investigated the structural changes that occurred in activated ED after plasma treatment using nuclear magnetic resonance (NMR). Hence, this study provides a new perspective on PAED for the field of plasma medicine.
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