ArticleHuman molecular genetics2016
Integrated analyses of gene expression and genetic association studies in a founder population.
Article in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Genetic variants of FER and SULF1 in the fibroblast-related genes are associated with non-small-cell lung cancer survival.International journal of cancer · 2025Article
- Advancing drug development for atrial fibrillation by prioritising findings from human genetic association studies.EBioMedicine · 2024Article
- Potentially functional variants ofFrontiers in immunology · 2024Article
- Exploring the Role of Enhancer-Mediated Transcriptional Regulation in Precision Biology.International journal of molecular sciences · 2023Review
- Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.Genome medicine · 2022Article
- Heritability estimation and differential analysis of count data with generalized linear mixed models in genomic sequencing studies.Bioinformatics (Oxford, England) · 2019Article
- Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.Communications biology · 2019Article
- Big data hurdles in precision medicine and precision public health.BMC medical informatics and decision making · 2018Article
- SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA.Genome research · 2018Article
- DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders.Molecular psychiatry · 2018Article
- Article
- Genetic analysis of deep phenotyping projects in common disorders.Schizophrenia research · 2018Review
- Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.PloS one · 2018Article
- Rare non-coding variants are associated with plasma lipid traits in a founder population.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Genome-wide association studies (GWASs) have become a standard tool for dissecting genetic contributions to disease risk. However, these studies typically require extraordinarily large sample sizes to be adequately powered. Strategies that incorporate functional information alongside genetic associations have proved successful in increasing GWAS power. Following this paradigm, we present the results of 20 different genetic association studies for quantitative traits related to complex diseases, conducted in the Hutterites of South Dakota. To boost the power of these association studies, we collected RNA-sequencing data from lymphoblastoid cell lines for 431 Hutterite individuals. We then used Sherlock, a tool that integrates GWAS and expression quantitative trait locus (eQTL) data, to identify weak GWAS signals that are also supported by eQTL data. Using this approach, we found novel associations with quantitative phenotypes related to cardiovascular disease, including carotid intima-media thickness, left atrial volume index, monocyte count and serum YKL-40 levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.