ReviewCold Spring Harbor perspectives in medicine2016
How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative.
Review in Cold Spring Harbor perspectives in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- A manually curated gene-phenotype catalogue for progeroid syndromes and premature aging.Aging · 2026Article
- Review
- The role of protective genetic variants in modulating epigenetic aging.GeroScience · 2025Article
- Characterization of Effects of mTOR Inhibitors on Aging in Caenorhabditis elegans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy.Human molecular genetics · 2023Article
- Article
- Lack of resemblance between Myhre syndrome and other "segmental progeroid" syndromes warrants restraint in applying this classification.GeroScience · 2021Article
- Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome.Aging · 2021Article
- Review of How Genetic Research on Segmental Progeroid Syndromes Has Documented Genomic Instability as a Hallmark of Aging But Let Us Now Pursue Antigeroid Syndromes!The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Review
- Mutations Involved in Premature-Ageing Syndromes.The application of clinical genetics · 2021Review
- Peptide Hormone Regulation of DNA Damage Responses.Endocrine reviews · 2020Review
- Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.Aging cell · 2020Article
- BiallelicMolecular syndromology · 2018Article
- Precision Medicine and Progress in the Treatment of Hutchinson-Gilford Progeria Syndrome.JAMA · 2018Article
- Geroscience: Addressing the mismatch between its exciting research opportunities, its economic imperative and its current funding crisis.Experimental gerontology · 2017Review
- Accelerated epigenetic aging in Werner syndrome.Aging · 2017Article
- WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.Human mutation · 2017Review
- Ageing: Dietary protection for genes.Nature · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Although translational applications derived from research on basic mechanisms of aging are likely to enhance health spans and life spans for most of us (the longevity dividend), there will remain subsets of individuals with special vulnerabilities. Medical genetics is a discipline that describes such "private" patterns of aging and can reveal underlying mechanisms, many of which support genomic instability as a major mechanism of aging. We review examples of three classes of informative disorders: "segmental progeroid syndromes" (those that appear to accelerate multiple features of aging), "unimodal progeroid syndromes" (those that impact on a single disorder of aging), and "unimodal antigeroid syndromes," variants that provide enhanced protection against specific disorders of aging; we urge our colleagues to expand our meager research efforts on the latter, including ancillary somatic cell genetic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.