Evidence map›Paper›PMID 26931446›Full record

SynthesisThe Journal of infectious diseases2016

Climatic Drivers of Diarrheagenic Escherichia coli Incidence: A Systematic Review and Meta-analysis.

Rebecca Philipsborn, Sharia M Ahmed, Berry J Brosi, Karen Levy

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
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  6. Waterborne diseases and climate change.Nature reviews. Microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rebecca PhilipsbornSchool of Medicine.
Sharia M AhmedDepartment of Environmental Health, Rollins School of Public Health.
Berry J BrosiDepartment of Environmental Sciences, Emory University, Atlanta, Georgia.
Karen LevyDepartment of Environmental Health, Rollins School of Public Health.
Emory University · USIndiana University School of Medicine

Funding

Impacts of Human Movement on Regional Strain Distribution of Diarrheagenic E.coliK01AI103544 · NIAID · EMORY UNIVERSITY · PI LEVY, KAREN · 2013 to 2017
$655k
Social Vulnerability and Climatic Drivers of Enteric Disease in Rural EcuadorR21TW009032 · FIC · EMORY UNIVERSITY · PI LEVY, KAREN · 2011 to 2011
$246k
FIC NIH HHS R21 TW009032NIAID NIH HHS K01 AI103544
6 · The paper itself

Abstract

backgroundPositive associations have been noted between temperature and diarrhea incidence, but considerable uncertainty surrounds quantitative estimates of this relationship because of pathogen-specific factors and a scarcity of data on the influence of meteorological factors on the risk of disease. Quantifying these relationships is important for disease prevention and climate change adaptation.

methodsTo address these issues, we performed a systematic literature review of studies in which at least 1 full year of data on the monthly incidence of diarrheagenic Escherichia coli were reported. We characterized seasonal patterns of disease incidence from 28 studies. In addition, using monthly time- and location-specific weather data for 18 studies, we performed univariate Poisson models on individual studies and a meta-analysis, using a generalized estimating equation, on the entire data set.

resultsWe found an 8% increase in the incidence of diarrheagenic E. coli (95% confidence interval, 5%-11%; P < .0001) for each 1°C increase in mean monthly temperature. We found a modest positive association between 1-month-lagged mean rainfall and incidence of diarrheagenic E. coli, which was not statistically significant when we controlled for temperature.

conclusionsThese results suggest that increases in ambient temperature correspond to an elevated incidence of diarrheagenic E. coli and underscore the need to redouble efforts to prevent the transmission of these pathogens in the face of increasing global temperatures.

Indexed as

Climate ChangeDiarrheaEscherichia coli InfectionsHumansIncidenceSeasonsTemperatureclimate changediarrheaEscherichia coliseasonality

Identifiers

PMID26931446
PMCPMC4907410
OpenAlexW2341365369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.