Evidence map›Paper›PMID 26931422›Full record

Trial reportEuropean journal of applied physiology2016

Effects of elastic band resistance training and nutritional supplementation on muscle quality and circulating muscle growth and degradation factors of institutionalized elderly women: the Vienna Active Ageing Study (VAAS).

Marlene Hofmann, Barbara Schober-Halper, Stefan Oesen, Bernhard Franzke, Harald Tschan, Norbert Bachl, Eva-Maria Strasser, Michael Quittan, Karl-Heinz Wagner, Barbara Wessner

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  3. Physical and Motor Fitness Tests for Older Adults Living in Nursing Homes: A Systematic Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Marlene HofmannResearch Platform Active Ageing, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Barbara Schober-HalperResearch Platform Active Ageing, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Stefan OesenResearch Platform Active Ageing, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Bernhard FranzkeResearch Platform Active Ageing, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Harald TschanCentre for Sport Science and University Sports, University of Vienna, Auf der Schmelz 6, 1150, Vienna, Austria.
Norbert BachlCentre for Sport Science and University Sports, University of Vienna, Auf der Schmelz 6, 1150, Vienna, Austria.
Eva-Maria StrasserKarl Landsteiner Institute for Remobilization and Functional Health and Institute for Physical Medicine and Rehabilitation, Social Medical Center South, Kundratstrasse 3, 1100, Vienna, Austria.
Michael QuittanKarl Landsteiner Institute for Remobilization and Functional Health and Institute for Physical Medicine and Rehabilitation, Social Medical Center South, Kundratstrasse 3, 1100, Vienna, Austria.
Karl-Heinz WagnerResearch Platform Active Ageing, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.
Barbara WessnerResearch Platform Active Ageing, University of Vienna, Althanstraße 14, 1090, Vienna, Austria. barbara.wessner@univie.ac.at.ORCID http://orcid.org/0000-0002-9061-7914
University of Vienna · ATKarl Landsteiner Society · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRegular resistance exercise training and a balanced diet may counteract the age-related muscular decline on a molecular level. The aim of this study was to investigate the influence of elastic band resistance training and nutritional supplementation on circulating muscle growth and degradation factors, physical performance and muscle quality (MQ) of institutionalized elderly.

methodsWithin the Vienna Active Ageing Study, 91 women aged 83.6 (65.0-92.2) years were randomly assigned to one of the three intervention groups (RT, resistance training; RTS, resistance training plus nutritional supplementation; CT, cognitive training). Circulating levels of myostatin, activin A, follistatin, IGF-1 and GDF-15, as well as MQ and functional parameters were tested at baseline as well as after 3 and 6 months of intervention.

resultsMQ of lower extremities significantly increased in the RT group (+14 %) and RTS group (+12 %) after 6 months. Performance improved in the RT and RTS groups for chair stand test (RT: +18 %; RTS: +15 %). Follistatin increased only in the RT group (+18 %) in the latter phase of the intervention, accompanied by a decrease in the activin A-to-follistatin ratio (-7 %). IGF-1, myostatin and GDF-15 levels were not affected by the intervention.

conclusionOur data confirm that strength training improves physical performance and MQ even in very old institutionalized women. This amelioration appears to be mediated by blocking muscle degradation pathways via follistatin rather than inducing muscle growth through the IGF-1 pathway. As plasma levels of biomarkers reflect an overall status of various organ systems, future studies of tissue levels are suggested.

Indexed as

ActivinsAgedAged, 80 and overAgingDietary SupplementsExerciseFemaleFollistatinGrowth Differentiation Factor 15HumansInsulin-Like Growth Factor IMuscle, SkeletalMyostatinResistance Trainingactivin AActivinsFollistatinGrowth Differentiation Factor 15Insulin-Like Growth Factor IMyostatinAgeingBlood-based biomarkersCirculating myokinesEssential amino acidsSarcopeniaStrength training

Identifiers

PMID26931422
PMCPMC4834098
OpenAlexW2290482622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.