Trial reportThe Journal of clinical psychiatry2016
A pilot randomized clinical trial evaluating the impact of genetic counseling for serious mental illnesses.
Trial report in The Journal of clinical psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00713804 (Genetic Counseling for Individuals With Mental Illness), which is not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Counseling for Individuals With Mental Illness: Impact on Knowledge, Risk Perception, Perceived Control and Internalized Stigma.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Control interventions in randomised trials among people with mental health disorders.The Cochrane database of systematic reviews · 2022Pooled it
- Decision coaching for people making healthcare decisions.The Cochrane database of systematic reviews · 2021Pooled it
- The Efficacy of Genetic Counseling for Psychiatric Disorders: a Meta-Analysis.Journal of genetic counseling · 2017Pooled it
- A Rapid Systematic Review of Outcomes Studies in Genetic Counseling.Journal of genetic counseling · 2017Pooled it
- A cluster randomized controlled trial of an online psychoeducational intervention for people with a family history of depression.BMC psychiatry · 2019Trial
- Potential for Genomics to Help Guide Preventive Strategies in Psychiatry.JAMA psychiatry · 2026Article
- Protocol for a new family history of addiction density score to aid in the treatment of alcohol and substance use disorders.Drug and alcohol dependence reports · 2025Article
- Genetic and Genomic Literacy of Healthcare Providers Treating Anorexia Nervosa in the United States: A Mixed Methods, Cross-Sectional Study.Brain and behavior · 2025Article
- Psychological state at the time of psychiatric genetic counseling impacts patient empowerment: A pre-post analysis.Journal of genetic counseling · 2025Article
- Genetic counselling for psychiatric conditions: exploring current perceptions of family physicians and psychiatrists in Portugal.Journal of community genetics · 2025Article
- Application of Genetic Testing for Anorexia Nervosa: An Ethical Analysis.Brain and behavior · 2025Article
- A survey in Austria supports the significance of genetic counseling and pharmacogenetic testing for mental illness.Frontiers in psychiatry · 2024Article
- How People With a Bipolar Disorder Diagnosis Talk About Personal Recovery in Peer Online Support Forums: Corpus Framework Analysis Using the POETIC Framework.JMIR medical informatics · 2023Article
- The impact of psychiatric disorders on caregivers: An integrative predictive model of burden, stigma, and well-being.Perspectives in psychiatric care · 2022Article
- An ethical analysis of divergent clinical approaches to the application of genetic testing for autism and schizophrenia.Human genetics · 2022Article
- Ethical concerns relating to genetic risk scores for suicide.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- The Role of Genetic Testing for Parkinson's Disease.Current neurology and neuroscience reports · 2021Review
- A review and definition of 'usual care' in genetic counseling trials to standardize use in research.Journal of genetic counseling · 2021Review
- Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map.Cold Spring Harbor perspectives in medicine · 2020Review
- Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review.Public health genomics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe serious mental illnesses schizophrenia, schizoaffective disorder, and bipolar disorder are complex conditions affecting 1% to 4% of the population. Individuals with serious mental illnesses express interest in genetic counseling, an intervention showing promise for increasing patient knowledge and adaptation. This trial aimed to evaluate the effects of genetic counseling for people with serious mental illnesses as compared to an educational intervention or wait list.
methodA pilot 3-arm (each n = 40; genetic counseling, a control intervention involving an educational booklet, or wait list), parallel-group, randomized clinical trial was conducted from September 2008 through November 2011 in Vancouver, Canada. Participants with schizophrenia, bipolar disorder, or schizoaffective disorder (DSM-IV) completed outcome measures assessing knowledge, risk perception, internalized stigma, and perceived control over illness at baseline and 1-month follow-up. The Brief Symptom Inventory was administered to control for current symptoms. Analyses included linear mixed-effects models and χ(2) tests.
resultsKnowledge increased for genetic counseling/educational booklet compared to wait list at follow-up (LRT1 = 19.33, Holm-adjusted P = .0003, R(2)LMM(m) = 0.17). Risk perception accuracy increased at follow-up for genetic counseling compared to wait list (Yates continuity corrected χ(2)1 = 9.1, Bonferroni P = .003) and educational booklet (Yates continuity corrected χ(2)1 = 8.2, Bonferroni P = .004). There were no significant differences between groups for stigma or perceived control scores.
conclusionsGenetic counseling and the educational booklet improved knowledge, and genetic counseling, but not the educational booklet, improved risk perception accuracy for this population. The impact of genetic counseling on internalized stigma and perceived control is worth further investigation. Genetic counseling should be considered for patients with serious mental illnesses.
trial registrationClinicalTrials.gov identifier: NCT00713804.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.