Evidence map›Paper›PMID 26930450›Full record

SynthesisBritish journal of cancer2016

Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis.

Cindy Ke Zhou, Siobhan Sutcliffe, Judith Welsh, Karen Mackinnon, Diana Kuh, Rebecca Hardy, Michael B Cook

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Prenatal Diethylstilbestrol Exposure and Cancer Risk in Males.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  5. Article
  6. Observational
  7. Early Life Exposures and Adult Cancer Risk.Epidemiologic reviews · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cindy Ke ZhouDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, NIH, DHHS, 9609 Medical Center Drive, MSC 9774, Bethesda, MD 20892-9774, USA.
Siobhan SutcliffeDivision of Public Health Sciences and the Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.
Judith WelshNIH Library, National Institutes of Health, Bethesda, MD, USA.
Karen MackinnonMedical Research Council Unit for Lifelong Health and Ageing, University College London, London, UK.
Diana KuhMedical Research Council Unit for Lifelong Health and Ageing, University College London, London, UK.
Rebecca HardyMedical Research Council Unit for Lifelong Health and Ageing, University College London, London, UK.
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, NIH, DHHS, 9609 Medical Center Drive, MSC 9774, Bethesda, MD 20892-9774, USA.

Funding

Intramural NIH HHSMedical Research Council MC_UU_12019/1
6 · The paper itself

Abstract

backgroundIt has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power.

methodsWe investigated birthweight in relation to prostate cancer in the Medical Research Council (MRC) National Survey of Health and Development (NSHD) using Cox proportional hazards models. We then conducted a meta-analysis of birthweight in relation to total and aggressive/lethal prostate cancer risks, combining results from the NSHD analysis with 13 additional studies on this relationship identified from a systematic search in four major scientific literature databases through January 2015.

resultsRandom-effects models found that per kg increase in birthweight was positively associated with total (OR=1.02, 95% confidence interval (95% CI)=1.00, 1.05; I(2)=13%) and aggressive/lethal prostate cancer (OR=1.08, 95% CI=0.99, 1.19; I(2)=40%). Sensitivity analyses restricted to studies with birthweight extracted from medical records demonstrated stronger positive associations with total (OR=1.11, 95% CI=1.03, 1.19; I(2)=0%) and aggressive/lethal (OR=1.37, 95% CI=1.09, 1.74; I(2)=0%) prostate cancer. These studies heavily overlapped with those based in Nordic countries.

conclusionsThis study provides evidence that heavier birthweight may be associated with modest increased risks of total and aggressive/lethal prostate cancer, which supports the hypothesis that intrauterine exposures may be related to subsequent prostate cancer risks.

Indexed as

Birth WeightCase-Control StudiesHumansMalePrognosisProstatic NeoplasmsRisk Assessment

Identifiers

PMID26930450
PMCPMC4955914

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.