Evidence map›Paper›PMID 26930409›Full record

ArticlePloS one2016

Cell Sheet Transplantation for Esophageal Stricture Prevention after Endoscopic Submucosal Dissection in a Porcine Model.

Guillaume Perrod, Gabriel Rahmi, Laetitia Pidial, Sophie Camilleri, Alexandre Bellucci, Amaury Casanova, Thomas Viel, Bertrand Tavitian, Christophe Cellier, Olivier Clement

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

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  9. Tissue Engineering for Gastrointestinal and Genitourinary Tracts.International journal of molecular sciences · 2022
    Review
  10. Effects of adipose tissue-derived mesenchymal stem cells and/or sildenafil citrate in experimental colon anastomosis model.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Guillaume PerrodUniversité Paris Descartes Sorbonne Paris cité, Assistance Publique-Hôpitaux de Paris, Department of Gastroenterology, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France.
Gabriel RahmiUniversité Paris Descartes Sorbonne Paris cité, Assistance Publique-Hôpitaux de Paris, Department of Gastroenterology, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France.
Laetitia PidialUniversité Paris Descartes Sorbonne Paris cité, Laboratoire imagerie de l'angiogenèse et plateforme d'imagerie du petit animal, UMR-S970, 56 rue Leblanc, 75015 Paris, France.
Sophie CamilleriUniversité Paris Descartes Sorbonne Paris cité, Assistance Publique-Hôpitaux de Paris, Department of Pathology, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France.
Alexandre BellucciUniversité Paris Descartes Sorbonne Paris cité, Laboratoire imagerie de l'angiogenèse et plateforme d'imagerie du petit animal, UMR-S970, 56 rue Leblanc, 75015 Paris, France.
Amaury CasanovaUniversité Paris Descartes Sorbonne Paris cité, Laboratoire imagerie de l'angiogenèse et plateforme d'imagerie du petit animal, UMR-S970, 56 rue Leblanc, 75015 Paris, France.
Thomas VielUniversité Paris Descartes Sorbonne Paris cité, Laboratoire imagerie de l'angiogenèse et plateforme d'imagerie du petit animal, UMR-S970, 56 rue Leblanc, 75015 Paris, France.
Bertrand TavitianUniversité Paris Descartes Sorbonne Paris cité, Laboratoire imagerie de l'angiogenèse et plateforme d'imagerie du petit animal, UMR-S970, 56 rue Leblanc, 75015 Paris, France.
Christophe CellierUniversité Paris Descartes Sorbonne Paris cité, Assistance Publique-Hôpitaux de Paris, Department of Gastroenterology, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France.
Olivier ClementUniversité Paris Descartes Sorbonne Paris cité, Laboratoire imagerie de l'angiogenèse et plateforme d'imagerie du petit animal, UMR-S970, 56 rue Leblanc, 75015 Paris, France.
Université Paris Cité · FRHôpital Européen Georges-Pompidou · FRAssistance Publique – Hôpitaux de Paris · FRDélégation Paris 5 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsExtended esophageal endoscopic submucosal dissection (ESD) is highly responsible for esophageal stricture. We conducted a comparative study in a porcine model to evaluate the effectiveness of adipose tissue-derived stromal cell (ADSC) double cell sheet transplantation.

methodsTwelve female pigs were treated with 5 cm long hemi-circumferential ESD and randomized in two groups. ADSC group (n = 6) received 4 double cell sheets of allogenic ADSC on a paper support membrane and control group (n = 6) received 4 paper support membranes. ADSC were labelled with PKH-67 fluorophore to allow probe-based confocal laser endomicroscopie (pCLE) monitoring. After 28 days follow-up, animals were sacrificed. At days 3, 14 and 28, endoscopic evaluation with pCLE and esophagography were performed.

resultsOne animal from the control group was excluded (anesthetic complication). Animals from ADSC group showed less frequent alimentary trouble (17% vs 80%; P = 0.08) and higher gain weight on day 28. pCLE demonstrated a compatible cell signal in 4 animals of the ADSC group at day 3. In ADSC group, endoscopy showed that 1 out of 6 (17%) animals developed a severe esophageal stricture comparatively to 100% (5/5) in the control group; P = 0.015. Esophagography demonstrated a decreased degree of stricture in the ADSC group on day 14 (44% vs 81%; P = 0.017) and day 28 (46% vs 90%; P = 0.035). Histological analysis showed a decreased fibrosis development in the ADSC group, in terms of surface (9.7 vs 26.1 mm²; P = 0.017) and maximal depth (1.6 vs 3.2 mm; P = 0.052).

conclusionIn this model, transplantation of allogenic ADSC organized in double cell sheets after extended esophegeal ESD is strongly associated with a lower esophageal stricture's rate.

Indexed as

Abdominal FatAnimalsCell Culture TechniquesCells, CulturedDissectionEndoscopy, GastrointestinalEsophageal NeoplasmsEsophageal StenosisEsophagusFemalePostoperative ComplicationsRadiographyStem Cell TransplantationSus scrofa

Identifiers

PMID26930409
PMCPMC4773126
OpenAlexW2289603159

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.