ArticleThe Journal of clinical endocrinology and metabolism2016
Association of Muscle Mass, Area, and Strength With Incident Diabetes in Older Adults: The Health ABC Study.
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Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 5 of them syntheses that pooled it.
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70citing papers in PubMed, 5 pooled it
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Who cites it
70 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Role of Fat-Free Mass in Weight-Related Complications: A Rapid Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies.British journal of sports medicine · 2026Pooled it
- Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review.Acta diabetologica · 2025Pooled it
- The Association between Body Composition using Dual energy X-ray Absorptiometry and Type-2 Diabetes: A Systematic Review and Meta-Analysis of Observational studies.Scientific reports · 2019Pooled it
- Cardiorespiratory fitness, muscular strength and risk of type 2 diabetes: a systematic review and meta-analysis.Diabetologia · 2019Pooled it
- The bidirectional relationship between diabetes and poor muscle function in older adults: data from two population-based studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Integrating Evidence on Dynapenia and Dynapenic Obesity: An Umbrella Review of Health Outcomes Among Community-Dwelling Older Adults.Healthcare (Basel, Switzerland) · 2026Review
- Associations between CT-based body composition parameters and glycemic control in adults with type 2 diabetes mellitus: a retrospective cohort study.Endocrine connections · 2026Article
- Association Between Body Composition and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Association between body composition measured using Dual-Energy X-Ray absorptiometry and incident type 2 diabetes mellitus in adults: A systematic review.Journal of diabetes and metabolic disorders · 2025Review
- Sex-specific associations between type 2 diabetes and muscle health in middle-aged adults.Diabetology & metabolic syndrome · 2025Article
- Lean body mass index and the risk of diabetes onset: A nationwide epidemiological cohort study.Journal of diabetes investigation · 2025Article
- Olfaction and diabetes among older adults.Chemical senses · 2025Article
- Muscle Mass and Muscle Strength in Non-Dialysis-Dependent Chronic Kidney Disease Patients.Journal of clinical medicine · 2024Article
- Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women.Metabolism open · 2024Article
- Associations of muscle mass and strength with new-onset diabetes among middle-aged and older adults: evidence from the China health and retirement longitudinal study (CHARLS).Acta diabetologica · 2024Article
- Associations of Abdominal Muscle Density and Area and Incident Cardiovascular Disease, Coronary Heart Disease, and Stroke: The Multi-Ethnic Study of Atherosclerosis.Journal of the American Heart Association · 2024Article
- An insight into the causal relationship between sarcopenia-related traits and venous thromboembolism: A mendelian randomization study.PloS one · 2024Article
- The relationship between fat distribution and diabetes in US adults by race/ethnicity.Frontiers in public health · 2024Article
- Establishing reference values for percentage of appendicular skeletal muscle mass and their association with metabolic syndrome in Korean adolescents.Annals of pediatric endocrinology & metabolism · 2023Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Britta A LarsenDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Christina L WasselDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Stephen B KritchevskyDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Elsa S StrotmeyerDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Michael H CriquiDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Alka M KanayaDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Linda F FriedDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Ann V SchwartzDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Tamara B HarrisDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Joachim H IxDepartment of Family Medicine and Public Health (B.A.L., M.H.C., I.X.), and Department of Medicine (J.H.I.), University of California, San Diego, San Diego, California 92093-0628; Department of Pathology and Laboratory Medicine (C.L.W.), College of Medicine, University of Vermont, Burlington, Vermont 05446; Wake Forest University and School of Medicine (S.B.K.), Winston-Salem, North Carolina 27157; Graduate School of Public Health (E.S.S.), University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Division of General Internal Medicine (A.M.K.), Department of Epidemiology and Biostatistics (A.V.S.), University of California, San Francisco, San Francisco, California 94143; University of Pittsburgh School of Medicine and Veterans Affairs Pittsburgh Healthcare System (L.F.F.), Pittsburgh, Pennsylvania 15261; and National Institute on Aging (T.B.H.), Bethesda, Maryland 20892.
Health ABC Study
Funding
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5MEnd of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7MPrimary Care-Based Physical Activity for Diabetic LatinasK01DK101650 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARSEN, BRITTA · 2014 to 2018
$699kNIA NIH HHS R01 AG028050NIDDK NIH HHS K01 DK101650NINR NIH HHS R01 NR012459
Abstract
contextSkeletal muscle plays a key role in glucose regulation, yet the association between muscle quantity or quality and the risk of developing type 2 diabetes has not been explored.
objectiveThe objective of the study was to assess the association between muscle quantity and strength and incident diabetes and to explore whether this association differs by body mass index (BMI) category. DESIGN AND
settingParticipants were 2166 older adults in the Health, Aging, and Body Composition Study who were free of diabetes at baseline (1997–1998). Computed tomography and dual-energy x-ray absorptiometry were used to measure abdominal and thigh muscle area and total body lean mass, respectively. Strength was quantified by grip and knee extensions.
main outcome measureIncident diabetes, defined as fasting glucose of 126 mg/dL or greater, a physician's diagnosis, and/or the use of hypoglycemic medication were measured.
resultsAfter a median 11.3 years of follow-up, there were 265 incident diabetes cases (12.2%). In fully adjusted models, no association was found between muscle or strength measures and incident diabetes (for all, P > .05). For women, there was a significant interaction with BMI category for both abdominal and thigh muscle, such that greater muscle predicted lower risk of incident diabetes for normal-weight women (hazard ratio 0.37 [0.17–0.83] and 0.58 [0.27–1.27] per SD, respectively) and a greater risk for overweight and obese women (hazard ratio 1.23 [0.98–1.54] and 1.28 [1.00–1.64], respectively). No significant interactions by BMI category existed for strength measures or any measures for men (for all, P > .05).
conclusionsGreater muscle area is associated with a lower risk of incident diabetes for older normal-weight women but not for men or overweight women.
Indexed as
Absorptiometry, PhotonAgedBlood GlucoseDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleMuscle, SkeletalMuscle StrengthOrgan SizeOverweightSex FactorsBlood Glucose
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