ReviewTherapeutic advances in gastroenterology2016
Diverticulosis today: unfashionable and still under-researched.
Review in Therapeutic advances in gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Are Nuts Safe in Diverticulosis? A Mixed-Methods Systematic Review of Available Evidence.Nutrients · 2025Pooled it
- Genetic, epigenetic and environmental factors in diverticular disease: systematic review.BJS open · 2024Pooled it
- Diverticulosis and cardiometabolic risk factors: a systematic literature review.International journal of colorectal disease · 2023Pooled it
- Epidemiology and risk factors for diverticular disease.Acta bio-medica : Atenei Parmensis · 2018Pooled it
- The DICA endoscopic score and the CODA clinical score may predict the severity of acute diverticulitis and the risk of hospitalisation: results from an international multicentre prospective cohort study.Techniques in coloproctology · 2026Article
- Article
- The Impact of Probiotics on Clinical Outcomes in Diverticular Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Global hospital-based disease management of acute diverticulitis: a prospective, international cohort study.EClinicalMedicine · 2025Article
- Identification of core gene-gut microbiome associations in diverticulitis patients through a two-sample mendelian randomization and bioinformatics-based investigation.Global medical genetics · 2025Article
- Impact of a Symbiotic Mixture on Moderate-to-severe Diverticular Disease of the Colon.Reviews on recent clinical trials · 2025Article
- Safety and efficacy of faecal microbiota transplantation in patients with acute uncomplicated diverticulitis: study protocol for a randomised placebo-controlled trial.Therapeutic advances in gastroenterology · 2025Article
- Article
- Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center.Frontiers in medicine · 2024Article
- Article
- Deciphering the gut microbiota's role in diverticular disease: insights from a Mendelian randomization study.Frontiers in cellular and infection microbiology · 2024Article
- The Impact of Educational Status on the Occurrence of Colonic Diverticula: Insights from an Austrian Cohort Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Article
- 150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility.Cell genomics · 2023Article
- Primary anastomosis with diverting loop ileostomy versus Hartmann's procedure for acute complicated diverticulitis: analysis of the National Inpatient Sample 2015-2019.International journal of colorectal disease · 2023Article
- Point-of-Care Abdominal Ultrasonography (POCUS) on the Way to the Right and Rapid Diagnosis.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverticulosis of the colon is a widespread disease, and its prevalence is increasing especially in the developing world. The underlying pathological mechanisms that cause the formation of colonic diverticula remain unclear but are likely to be the result of complex interactions among age, diet, genetic factors, colonic motility, and changes in colonic structure. The large majority of patients remain asymptomatic throughout their life, one fifth of them become symptomatic (developing the so-called 'diverticular disease') while only a minority of these will develop acute diverticulitis. The factors predicting the development of symptoms remain to be identified. Again, it is generally recognized that diverticular disease occurrence is probably related to complex interactions among colonic motility, diet, lifestyle, and genetic features. Changes in intestinal microflora due to low-fiber diet and consequent low-grade inflammation are thought to be one of the mechanisms responsible for symptoms occurrence of both diverticular disease and acute diverticulitis. Current therapeutic approaches with rifaximin and mesalazine to treat the symptoms seem to be promising. Antibiotic treatment is currently advised only in acute complicated diverticulitis, and no treatment has currently proven effective in preventing the recurrence of acute diverticulitis. Further studies are required in order to clarify the reasons why diverticulosis occurs and the factors triggering occurrence of symptoms. Moreover, the reasons why rifaximin and mesalazine work in symptomatic diverticular disease but not in acute diverticulitis are yet to be elucidated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.