ReviewClinics in colon and rectal surgery2016
Screening, Surveillance, and Treatment of Anal Intraepithelial Neoplasia.
Review in Clinics in colon and rectal surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Safety and immunogenicity of VGX-3100 formulations in a healthy young adult population.Human vaccines & immunotherapeutics · 2020Trial
- Topical Protease Inhibitor Increases Tumor-Free and Overall Survival in CD4-Depleted Mouse Model of Anal Cancer.Viruses · 2024Article
- Case Report: Resolution of high grade anal squamous intraepithelial lesion with antibiotics proposes a new role for syphilitic infection in potentiation of HPV-associated ASCC.Frontiers in oncology · 2023Article
- Progression of Anal Intraepithelial Neoplasia to Cancer Is Low with Anoscopy Surveillance and Treatment.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Gene methylation of CADM1 and MAL identified as a biomarker of high grade anal intraepithelial neoplasia.Scientific reports · 2022Article
- Anal Intraepithelial Neoplasia: Precursor of Anal Squamous Cell Carcinoma.Journal of the anus, rectum and colon · 2022Review
- The other side of screening: predictors of treatment and follow-up for anal precancers in a large health system.AIDS (London, England) · 2021Article
- A 12-year retrospective evaluation of anal pre-cancerous lesions and cancer in people living with HIV-1 infection in the Southeastern U.S.Infectious agents and cancer · 2021Article
- Anal squamous intraepithelial lesions: an update and proposed management algorithm.Techniques in coloproctology · 2020Review
- A Cell-BasedSLAS discovery : advancing life sciences R & D · 2020Article
- Anal Intraepithelial Neoplasia from a Pathologists Point of View.Clinics in colon and rectal surgery · 2018Review
- Basic Science, Epidemiology, and Screening for Anal Intraepithelial Neoplasia and Its Relationship to Anal Squamous Cell Cancer.Clinics in colon and rectal surgery · 2018Review
- Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions.AIDS (London, England) · 2018Article
- Anal intraepithelial neoplasia: A review of diagnosis and management.World journal of gastrointestinal oncology · 2017Review
- Human Papillomavirus in Kidney Transplant Recipients.Seminars in nephrology · 2016Review
- Anal intraepithelial neoplasia: diagnosis, screening, and treatment.Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of anal intraepithelial neoplasia has been increasing, especially in high-risk patients, including men who have sex with men, human immunodeficiency virus positive patients, and those who are immunosuppressed. Several studies with long-term follow-up have suggested that rate of progression from high-grade squamous intraepithelial lesions to invasive anal cancer is ∼ 5%. This number is considerably higher for those at high risk. Anal cytology has been used to attempt to screen high-risk patients for disease; however, it has been shown to have very little correlation to actual histology. Patients with lesions should undergo history and physical exam including digital rectal exam and standard anoscopy. High-resolution anoscopy can be considered as well, although it is of questionable time and cost-effectiveness. Nonoperative treatments include expectant surveillance and topical imiquimod or 5-fluorouracil. Operative therapies include wide local excision and targeted ablation with electrocautery, infrared coagulation, or cryotherapy. Recurrence rates remain high regardless of treatment delivered and surveillance is paramount, although optimal surveillance regimens have yet to be established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.