ReviewJournal of pain research2016
Idiopathic intracranial hypertension: ongoing clinical challenges and future prospects.
Review in Journal of pain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Effectiveness of Topiramate Versus Acetazolamide in the Management of Idiopathic Intracranial Hypertension: ASystematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Primary Empty Sella Syndrome and the Prevalence of Hormonal Dysregulation.Deutsches Arzteblatt international · 2018Pooled it
- Automated Retinal Vascular Analysis Reveals Response to Acetazolamide in Idiopathic Intracranial Hypertension.Translational vision science & technology · 2025Trial
- Spinal cord tumors misdiagnosed as idiopathic intracranial hypertension: Case report with literature review.The journal of spinal cord medicine · 2026Review
- Visual and headache outcomes following lumboperitoneal shunting in idiopathic intracranial hypertension: a prospective observational study.BMC neurology · 2026Observational
- Obstruction caused by suprasellar cisterna arachnoid cyst expansion after ventriculoperitoneal shunt in children with hydrocephalus.Pediatric investigation · 2025Article
- Weight loss and a shunt on "off": an odd case of overshunting in an idiopathic intracranial hypertension patient. Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A Prospective Multicenter Study on the Evaluation of Frequency of Idiopathic Intracranial Hypertension in Korea.Journal of Korean medical science · 2025Observational
- Venous sinus stenting versus ventriculoperitoneal shunting: Comparing perioperative costs for idiopathic intracranial hypertension.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Vaulting further: cranial vault expansion for craniocerebral disproportion without primary craniosynostosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Review
- Optic Disc Swelling in Cancer Patients: Etiology and Implications.Journal of clinical medicine · 2023Article
- Transverse Sinus Stenting Reverses Medically Refractory Idiopathic Intracranial Hypertension.Frontiers in ophthalmology · 2022Article
- Case Report: Interferon-Alpha-Induced Neuromyelitis Optica Spectrum Disorder.Frontiers in neurology · 2022Article
- The Case of a Patient with Idiopathic Intracranial Hypertension Who Required Additional Stenting for Stent-Adjacent Stenosis.Journal of neuroendovascular therapy · 2022Article
- Bridging the Gap between Ophthalmology and Emergency Medicine in Community-Based Emergency Departments (EDs): A Neuro-Ophthalmology Guide for ED Practitioners.Clinics and practice · 2021Article
- Long-term telemetric intracranial pressure monitoring for diagnosis and therapy optimisation of idiopathic intracranial hypertension.BMC neurology · 2021Article
- An update on idiopathic intracranial hypertension in adults: a look at pathophysiology, diagnostic approach and management.Journal of neurology · 2021Review
- Management of the regression of papilledema with regional axon loss in idiopathic intracranial hypertension patients.International ophthalmology · 2021Article
- Pituitary Volume in Patients with Primary Empty Sella and Clinical Relevance to Pituitary Hormone Secretion: A Retrospective Single Center Study.Current medical imaging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic intracranial hypertension (IIH) is an uncommon disorder characterized by increased intracranial pressure without radiological or laboratory evidence of intracranial pathology except empty sella turcica, optic nerve sheath with filled out cerebrospinal fluid spaces, and smooth-walled nonflow-related venous sinus stenosis or collapse. This condition typically affects obese women. The incidence of IIH is increasing with the rising prevalence of obesity. Persistent headache is the most common symptom. Visual impairment is a serious complication that may not be recognized by the patients. This paper reviews clinical manifestations, diagnostic challenges, and current treatments of IIH in adults. Various imaging modalities have been studied on their validity for detection of IIH and papilledema. This review also includes new studies on medical, surgical, and interventional management of this condition. Acetazolamide and topiramate are the only two medications that have been studied in randomized controlled trials about their efficacy in treatment of IIH. In patients who have severe visual impairment or progressive visual deterioration despite medical management, surgical or interventional treatment may be considered. The efficacy and complications of cerebrospinal fluid diversion, optic nerve sheath fenestration, and endovascular venous stenting reported in the last 3 decades have been summarized in this review. Finally, the prospective aspects of biomarkers and treatments are proposed for future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.